Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Exploring the Ameliorative Potential of Barleria cristata in Cognitive Dysfunction Rat Model: Investigating Behavioral, Biochemical and Cellular Changes

1, 2, 3, 4, 5, 6

  1. 1Department of Pharmacology, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Secunderabad, Telangana, INDIA.
  2. 2Department of Pharmacology, School of Pharmaceutical Sciences and Technologies, JNTUK, Kakinada, Andhra Pradesh, INDIA.
  3. 3Department of Pharmacology, CMR College of Pharmacy, Kandlakoya, Medchal, Telangana, INDIA.
  4. 4Department of Pharmacology, Vignan Institute of Pharmaceutical Technology, Kapujaggarajupeta, Visakhapatnam, INDIA.
  5. 5Department of Pharmacology St Mary’s College of Pharmacy, St.Francis street, Hyderabad, Telangana, INDIA.
  6. 6Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy, Nizampet, Hyderabad, Telangana, INDIA.

CORRESPONDENCE

Dr. Koppala Rakesh Viswa Sai Chaitanya

Department of Pharmacology, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Secunderabad. Telangana, INDIA.

koppala526@gmail.com

Received: 27-07-2024; Revised: 17-01-2025; Accepted: 09-05-2025.

Volume 59, Issue 3s (Supplement) · pp. s950-s960 · 2025 · DOI: 10.5530/ijper.20250416

ABSTRACT

Background: Cognitive impairment is a pervasive and perplexing concern that transcends the boundaries of various neuropsychiatric disorders like schizophrenia and Alzheimers. As research continues to unravel the intricacies of Barleria cristata's bioactive compounds, it offers promising prospects for the new therapeutic agents in the realm of natural medicine.Materials and Methods: In present study the ameliorative effect of methanolic leaf extract of Barleria cristata in ketamine induced cognitive dysfunction in rats. Locomotor activity (forced swim test), step down latency and transfer latency were determined for behavioral assessment followed by biochemical estimation of malondialdehyde, reduced glutathione and catalase activity Results: Barleria cristata methanolic extract treatment significantly mitigated cognitive impairment in ketamine induced rats with improvement in short and long term memory. Furthermore, it significantly reduced the lipid peroxidation and improved the levels of reduced glutathione and catalase in rats. On histopathological examination Barleria cristata methanolic extract revealed dose-dependent substantial neuroprotection, by maintaining normal neurons with less neurodegenerative changes.Conclusion: Barleria cristata methanolic extract effectively mitigates cognitive impairment, oxidative stress and neurodegeneration in ketamine-induced rats, demonstrating significant neuroprotective properties.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Chaitanya, K. R. V. S., Korimelli, S., Gaddam, S. R., Kavya, M., Chandupatla, R., & Anusha, V. R. S. (2025). Exploring the Ameliorative Potential of Barleria cristata in Cognitive Dysfunction Rat Model: Investigating Behavioral, Biochemical and Cellular Changes. Indian Journal of Pharmaceutical Education and Research, 59(3s), s950-s960. https://doi.org/10.5530/ijper.20250416

    Copyright and licence

    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0