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Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD

1, 2

  1. 1Department of Pharmaceutical Technology, Ganpat University, Kherva, Mehsana, Gujarat, INDIA.
  2. 2Department of Pharmaceutics, School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.

CORRESPONDENCE

Shyam Sunder Pancholi

Department of Pharmaceutics School of Pharmacy and Technology Management (SPTM) SVKM’s NMIMS (Deemed to be University) Mukesh Patel Technology Park, Babulde, Shirpur, Dhule, Maharashtra, INDIA.

sspancholi@gmail.com

Received: 04-08-2025; Revised: 29-09-2025; Accepted: 03-11-2025.

Volume 60, Issue 2s (Supplement) · pp. s443-s461 · 2026 · DOI: 10.5530/ijper.20261364

ABSTRACT

Aim: Quality by Design (QbD)-Optimized Spray-Dried Microparticles (prepared by using spray drying process) of Posaconazole-Loaded Chitosan Nanoparticles (POS-CSNPs) for enhanced antifungal efficacy.Materials and Methods: Box-Behnken Design (BBD) a systematic design of experiments was implemented, to screen and optimize the formulation variables for the intended qualities.Results: Outcomes showed that POS-CSNPs have particle size (259.33±6.82 nm), Poly dispersity Index (0.192±0.010), zeta potential (-31.23±0.84 mV) and %Entrapment Efficiency (65.17±1.71). In vitro fungal study result showed the enhanced antifungal and higher fungicidal effect on Rhizopus oryzae strains.Conclusion: From the result it is concluded that the preparation of POS-CSNPs have higher anti-fungal effect on fungus strain.

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    Singh, S. K., & Pancholi, S. S. (2026). Design and Development of Chitosan-Based Posaconazole Loaded Dry Powder by Using BBD. Indian Journal of Pharmaceutical Education and Research, 60(2s), s443-s461. https://doi.org/10.5530/ijper.20261364

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    © 2026 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0