Formulation and Evaluation of Beclomethasone Dipropionate Loaded Niosomal Gel for Topical Use
1, 1, 2, 1, 1, 1, 1
- 1Dayanand Education Society’s, Dayanand College of Pharmacy, Barshi Road, Latur, Maharashtra, INDIA.
- 2School of Pharmacy, MIT Vishwaprayag University, Solapur-Pune Highway, Kegaon, Solapur, Maharashtra, INDIA.
CORRESPONDENCE
Rohit Sarda, Dayanand Education Society’s, Dayanand
College of Pharmacy, Barshi Road, Latur, Maharashtra, INDIA.
Received: 19-01-2026; Accepted: 08-05-2026.
Volume 60, Issue 3s (Supplement) · pp. s918-s928 · 2026 · DOI: 10.5530/ijper.20260326
ABSTRACT
Background: The present study focuses on the formulation and evaluation of a niosomal gel containing beclomethasone dipropionate for topical delivery, with the objective of enhancing skin permeability and achieving sustained drug release. Niosomes, which are spherical vesicles composed of non-ionic surfactants, offer several advantages over conventional drug delivery systems, including higher drug loading capacity, controlled release, and reduced systemic side effects.Materials and Methods: In this study, niosomes were prepared using the thin-film hydration technique by optimizing the ratios of Span 60 and cholesterol. The prepared niosomal dispersions were subsequently incorporated into a Carbopol-based gel and subjected to comprehensive evaluation. Evaluation Parameters: Various parameters, including vesicle size, entrapment efficiency, pH, spreadability, drug content, and in vitro drug release, were assessed. Results/Conclusion: The results demonstrated that the optimized niosomal gel possessed favorable physicochemical properties, exhibited sustained drug release, and showed significant potential as an effective topical drug delivery system.
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Birajdar, M., Sarda, R., Tiwari, S., Jadhav, D., Sonvane, S., Shivnechari, P., & Satpute, K. (2026). Formulation and Evaluation of Beclomethasone Dipropionate Loaded Niosomal Gel for Topical Use. Indian Journal of Pharmaceutical Education and Research, 60(3s), s918-s928. https://doi.org/10.5530/ijper.20260326
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