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Formulation Considerations and in vitro Characterization of Polymeric Micelles Loaded with Asenapine Maleate

1, 1, 2

  1. 1Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, IRAQ.
  2. 2Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IRAN.

CORRESPONDENCE

Nawal Ayash Rajab

Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, IRAQ.

dr.nawalayash@copharm.uobaghdad.edu.iq

Received: 03-04-2026; Accepted: 19-08-2026.

Volume 60, Issue 4s · pp. s1461-s1473 · 2026 · DOI: 10.5530/ijper.20263858

ABSTRACT

Objectives: An effort has been utilized to incorporate ASPM into polymeric micelles using single and mixed copolymers.Materials and Methods: A thin-film hydration approach was used to create the ASPM polymeric micelles, which comprised TPGS, Solutol®HS-15, and Pluronics. Micelles characterization was performed by particle size distribution, zeta potential, while Encapsulation Efficiency (EE%), Drug Loading (DL%) content and in vitro drug release were determined also by HPLC analysis.Results: The ASPM loaded micelles, specifically F1, F4, and F8, exhibited a mean particle size of less than 200 nm, characterized by a narrow size distribution. The encapsulation rate reached up to 72±1.571%, with a drug loading of 14.12±0.3%, and a zeta potential indicating a negative charge of approximately -2 mV. ASPM was continuously released from polymeric micelles in PBS medium (pH 7.4) for 6 hr at 37°C, F8 was selected as the optimized mixed polymeric micelle.Conclusion: Polymeric micelles composed of TPGS, Tetronic® and TPGS:Solutol®HS 15 at concentration (2% w/v) can effectively incorporate ASPM and prolong drug release.

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    Jassim, Z. E., Rajab, N. A., & Javar, H. A. (2026). Formulation Considerations and in vitro Characterization of Polymeric Micelles Loaded with Asenapine Maleate. Indian Journal of Pharmaceutical Education and Research, 60(4s), s1461-s1473. https://doi.org/10.5530/ijper.20263858

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    © 2026 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0