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Solid Self-Nanoemulsifying Drug Delivery System of Meclizine HCl: In vitro Dissolution and ex vivo Intestinal Permeation Study for Oral Delivery

1, 1, 1

  1. 1Department of Pharmaceutics, PESU Institute of Pharmacy, PES University, EC Campus, Bengaluru, Karnataka, INDIA.

CORRESPONDENCE

Prajwal Bangalore Venkatesh

Department of Pharmaceutics, PESU Institute of Pharmacy, PES University, EC Campus, Bengaluru, Karnataka, INDIA.

prajuprajwal7073@gmail.com

Volume 60, Issue 5 (KrupaPharmaCon 2026) · pp. 66-75 · 2026 · DOI: 10.5530/ijper.krupapharmacon.24

ABSTRACT

Background: Meclizine hydrochloride Solid Self-Nanoemulsifying Drug Delivery System S-SNEDDS) was formulated and optimized to improve solubility and intestinal absorption.Objectives: Solubility studies identified Transcutol HP (25 ± 1.2 mg/mL), Tween 80 (30 ± 2 mg/ mL), and Capryol 90 (30 ± 1.5 mg/mL) as ideal excipients.Materials and Methods: A Surfactant-cosurfactant mixture ratio of 1:2 yielded a broad nanoemulsion zone with stable Grade A emulsions. Thermodynamic stability was confirmed through stress tests. The optimized SNEDDS had a droplet size of 130.4 nm, PDI of 0.442, and -14.1 mV of zeta potential. X-ray Diffraction confirmed the drug’s amorphous state, while Fourier Transfer Infrared Spectroscopy revealed no drug-excipient interaction.Results: Scanning Electron Microscope images showed successful solidification with Neusilin US2, and excellent flow properties were observed.Conclusion: In vitro drug release exceeded 95% within 30 min compared to 55.96% for the pure drug. Ex vivo studies demonstrated enhanced permeability through the intestinal membrane (SNEDDS: 98.45%, S-SNEDDS: 96.15%) vs. pure drug (60.1%), suggesting improved oral bioavailability.

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    Ravikumar, M. G., Raju, P. S., & Venkatesh, P. B. (2026). Solid Self-Nanoemulsifying Drug Delivery System of Meclizine HCl: In vitro Dissolution and ex vivo Intestinal Permeation Study for Oral Delivery. Indian Journal of Pharmaceutical Education and Research, 60(5), 66-75. https://doi.org/10.5530/ijper.krupapharmacon.24

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    © 2026 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0