Table of Contents

Original Article(continued)

1. Determination of Anti-Cancer and Photo-Aging Potential of Ripened Carica papaya Fruit Extract in in vitro Cell Line Models

   Manali Pradhan, Rajasekaran Raja, Rohit Sharma Sharma, Bharti Rathod, Debjani Dasgupta, Arindam Banerjee

   pp. s607-s616 · DOI: 10.5530/ijper.20261711 · 2026

   Aim and Background: Carica papaya has been widely used in traditional medicine. However, the ripened papaya fruit remains underexplored regarding its potential as an anti-cancer and photo-aging aspect. Thus, our aim is t…

   TextPDFLens

2. Combined Raft Formation-Interpenetrating Complex Approach to Reconstitutable Sustained-Release Suspension Development

   Pallavi Asaram Chandewar, Dilesh Jagdish Singhavi, Prachi Pradiprao Gedam, Nilesh Ashok Karande, Rajendra Onkarappa Ganjiwale

   pp. s617-s626 · DOI: 10.5530/ijper.20261811 · 2026

   Background: The foundation of this work is the use of raft formation and Interpenetrating Polymeric Network (IPN) complexation techniques to create a reconstitutable sustained-release suspension of Diltiazem Hydrochlorid…

   TextPDFLens

3. Synthesis and Evaluation of Mutual Prodrug of Mefenamic Acid and Etodolac with Sesamol for the Treatment of Alzheimer's Disease

   Prayaga Rajappan Krishnendu, Shebina Pareed Rasheed, Vibina Kaippollil, Arun Rasheed, Jibin Joy, Pattilthodika Suhail

   pp. s627-s637 · DOI: 10.5530/ijper.20261831 · 2026

   Background: Epidemiological and clinical trial data suggest that NSAIDs can be used for managing Alzheimer's disease. This research area began with the observation of reduced incidence and progression of Alzheimer's dise…

   TextPDFLens

4. Evaluation of Anti-Arthritic Effect of Red Sandalwood and Curcumin Combination (Orthorev Oil)® on Topical Application in Rats

   Jayshree Shriram Dawane, Priti Pravin Dhande

   pp. s638-s643 · DOI: 10.5530/ijper.20262483 · 2026

   Background: Arthritis, a common and debilitating condition characterized by joint inflammation, pain, and stiffness, affects millions of individuals worldwide. The standard treatment for arthritis is effective, but often…

   TextPDFLens

5. Emerging Trends and Conceptual Mapping in Network Pharmacology Research: A Bibliometric Analysis (2008-2023) Using VOSviewer

   Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Saleh M Abdullah, Saeed Alshahrani, Ahmad Assiri, Jobran M Moshi, Nizar A. Khamjan, Humaid Al-shamsi, Abrar Fahad Alshahrani, Syam Mohan

   pp. s644-s655 · DOI: 10.5530/ijper.20262593 · 2026

   Background: Network Pharmacology (NP) aims to understand drug actions and their interactions with multiple targets using computational methods. Objectives: This provides a network-based approach to comprehensively invest…

   TextPDFLens

6. Herbal Nanoparticle-Embedded Film-Forming Spray: A Novel Topical Delivery System for Vitiligo Management

   Madhuri H Rayabagi, Bijal Prajapati

   pp. s656-s668 · DOI: 10.5530/ijper.20262653 · 2026

   Objectives: This study evaluated a topical film-forming spray designed to improve the skin permeation of curcumin and piperine-loaded nanoparticles, aiming to enhance therapeutic efficacy and reduce dosing frequency for …

   TextPDFLens

7. Unmasking the Therapeutic Potential of a Bio-enhanced Phloretin Formulation: Formulation, Characterization, and Evaluation

   Niyamat M.A. Chimthanawala, Purnima D. Amin, Sadhana S. Sathaye

   pp. s669-s686 · DOI: 10.5530/ijper.20264165 · 2026

   Introduction: Phloretin (PHL, 3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl) propan-1- one), is a naturally occurring dihydrochalcone, exclusively found in apple fruit peels, leaves, and Manchurian apricots. It has treme…

   TextPDFLens

8. Experimental Research of Ions in Wound Healing Via Film Forming Solution

   Ketura Kambampaty, Nagesh Chandrashekhar Setty, Suma Naduvinamani, Kartik Bhairu Khot, Sibghatullah Muhammad Ali Sangi, Sreeharsha Nagaraja, Girish Meravanige, Mohammed Monirul Islam, Pavan Kumar Sreenivasalu, Shahzad Chohan

   pp. s687-s698 · DOI: 10.5530/ijper.20264372 · 2026

   Objectives: This study aimed to investigate the wound healing potential of Film Forming Solution (FFS) incorporated with Silver (Ag) and Copper Oxide (CuO) Nanoparticles (NPs). Materials and Methods: Ag NPs were synthesi…

   TextPDFLens

9. Comparative Evaluation of Co-Crystallization Methods for the Solubility Enhancement of Poorly Water-Soluble Drug of BCS Class II

   Harish K H, Leejoan D’souza, Sanatkumar Bharamu Nyamagoud, M Mahesh Yadav

   pp. s699-s709 · DOI: 10.5530/ijper.20264678 · 2026

   Background: The practice of co-crystallizing 2 or more components has gained increasing popularity to create novel materials with enhanced performance and properties compared to those composed solely of pure components. …

   TextPDFLens

10. Nasal Delivery of Nanoemulsion Containing a Synergistic Combination of Curcumin and Gefitinib for Brain Tumor Targeting

    Sagar Kishor Savale, Sachin Maroti Chandankar, Hitendra Shaligram Mahajan

    pp. s710-s720 · DOI: 10.5530/ijper.20265250 · 2026

    Objectives: This study involves combination therapy of anticancer drugs (curcumin and gefitinib) as nanoemulsion and their application for treating human glioblastoma U373MG cell lines. Materials and Methods: Nanoemulsio…

    TextPDFLens

11. High-Dose Ashwagandha Extract: A Toxicological Assessment in Male Wistar Rats Using a Dose-Dependent Approach

    Enas Sayed Gad, Afnan Omar Buobaid, Aisha Yousef ALfraih, Graham Mohammed Alanazi, Mariyayah Abdullah Alrashid, Maisaa Ibrahim Alessa, Nora Adel Alduhayyan, Rasha Naser Aldossari

    pp. s721-s727 · DOI: 10.5530/ijper.20263686 · 2026

    Background/Aim: The rising utilization of Ashwagandha (Withania somnifera), a well-known adaptogen and herbal supplement, has prompted apprehensions over its safety at elevated dosages. This study examines the potential …

    TextPDFLens

12. In vivo and in vitro Evaluation of Polymeric Gel Loaded with Biologically Synthesized Black Tea and Baliospermum solanifolium Silver Nanoparticle

    Sarika Nikam, Shilpa Chaudhari, Priyatama Powar

    pp. s728-s738 · DOI: 10.5530/ijper.20266071 · 2026

    Aim: The overall objective of the study was to synthesise and assess a polymeric gel that contained biologically synthesised Silver Nanoparticles (AgNPs). Materials and Methods: AgNPs were produced through the reduction …

    TextPDFLens

13. Design and Development of Simple Liquid Chromatographic Technique for the Rapid Determination of Ruxolitinib (RUXO) in Bulk Drugs along with Characterization of Forced Degradation Studies

    Sarangadhara Sahu, Susanta Kumar Panda, Sudhir Kumar Sahoo, Madhusmruti Khandai, Amaresh Prusty

    pp. s739-s747 · DOI: 10.5530/ijper.20262561 · 2026

    Objectives: The motive behind this work is to develop a simple, rapid, accurate, and precise High-Performance Liquid Chromatography (HPLC) method for determining Ruxolitinib (RUXO) in bulk drugs and to study drug degrada…

    TextPDFLens

14. To Evaluate the Affinity of Chlorogenic Acid and Ferulic Acid towards PPAR-Γ and Glutathione S-Transferase Omega-1 Complex with the Docking Simulation and their Pharmacological Activities by Using their Formulation

    Pallavi Patil, Neha Shegokar, Vitthal Chopade, Sandhya Bagde

    pp. s748-s757 · DOI: 10.5530/ijper.20266738 · 2026

    Objectives: The aim of this study was to perform molecular docking and ADMET analyses of ferulic acid and chlorogenic acid. Through molecular docking, we have observed the receptor affinity, specifically targeting the PP…

    TextPDFLens

15. Screening, Optimization and Production of Uricase from a Novel Actinomycete Isolate A85

    Anand Kumar Dakuri, Girijasankar Guntuka, Sowjanya Gurugubelli, Mobeen Shaik, Sandeep Venkata Chalapathi

    pp. s758-s767 · DOI: 10.5530/ijper.20264421 · 2026

    Background: Uricase is used to diagnose the presence of uric acid in biological fluids as well as to cure gout. Uric acid concentrations in -biological fluids are elevated by several medical disorders. Chronic renal diso…

    TextPDFLens

16. Formulation and Evaluation of Nanocrystals of Hydrochlorothiazide

    Kumar Mithun, Kumar Anoop, Pathak Divya

    pp. s768-s775 · DOI: 10.5530/ijper.20264915 · 2026

    Aim/Background: Hydrochlorothiazide (HTZ) is a diuretic derivative and used as an antihypertensive agent with low bioavailability (around 60%) due to impaired dissolution rate. Further, excretion of HTZ is high due to ra…

    TextPDFLens

17. Optimizing Tumor-Targeting Drug Delivery of Potent Anti-Cancer Drug Using Doe-Guided Solid Lipid Nanoparticle Formulation: In vitro Cell Line Studies and Histopathological Analysis

    Ramineni Sunitha, Praveen Sivadasu, Pathange Bharghava Bhushan Rao, Raghavendra Kumar Gunda

    pp. s776-s793 · DOI: 10.5530/ijper.20261953 · 2026

    Background: Lapatinib Ditosylate emerges as a notable contender; it functions as potent selective dual tyrosine kinases ErbB-2 and EGFR inhibitor and it is a class-II drug. The present work focuses on the development of …

    TextPDFLens

18. Risk Factor Analysis in Diabetes and Hypertension Patients from Odisha, India: A Cross-Sectional Study

    Prabhudatta Mohapatra, Ashrumochan Debata, Rohan Kumar Pradhan, Karmajeet Rath, Swayamsidha Mangaraj, Mihir Kumar Kar, Durga Madhab Kar

    pp. s794-s804 · DOI: 10.5530/ijper.20262353 · 2026

    Objectives: This study aims to investigate the incidence of poor glycemic control among elderly diabetic individuals with hypertension in urban areas of Odisha, India. This observational cross-sectional study was conduct…

    TextPDFLens

19. In silico and in vitro Investigation of Osteogenesis Potentiality of Smilax china Hydro Alcoholic Root Extract on Human Osteoblast-like Cell Line (Saos2)-A Novel Approach

    Hafiz A. Makeen, Mohammed Albratty

    pp. s805-s814 · DOI: 10.5530/ijper.20263810 · 2026

    Background: Osteoporosis is a skeletal illness characterised by the breakdown of bone tissue's micro-architecture, which increases the risk of fractures by making bones more brittle. Nowadays, the herbal based therapies …

    TextPDFLens

20. Formulation and Evaluation of a Bromelain-Loaded Nanoemulgel for Effective Acne Treatment

    Archana S Patil, Pratik Ugare, Arpana Patil, Sheetal Patil, Rajashree Masareddy

    pp. s815-s825 · DOI: 10.5530/ijper.20261446 · 2026

    Aim: This study aimed to design, optimize, and evaluate a bromelain-infused nanoemulgel to enhance its transdermal delivery and improve therapeutic outcomes in the management of Acne vulgaris. Background: Acne vulgaris r…

    TextPDFLens