Volume 61, Issue 1

Original Article(continued)

1. In vitro Investigation of Conessine-Mediated Apoptosis on Human Breast Cancer Cell Line (MCF-7) via Mitochondrial Pathway and APAF-1 Gene

   Ahad Amer Alsaiari, Hanadi M Zbrmawi, Jawaher Amer Alsaiari, Mariam M Jaddah, Aisha Abdullah Alshanqiti, Amal Saeed Al Ayed, Hanan Salem Alghamdi

   pp. 222-230 · DOI: 10.5530/ijper.20274669 · 2026

   Background: Breast cancer was the second most deadly cancer, especially in women. Recent data show that the incidence rate has been slowly rising over time and now it is becoming a global problem. This increasing problem…

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2. Effect of Baicalin on Placental Tissue Damage in Preeclampsia Rats via the IL-33/ST2 Pathway

   Shuyun Ding, Li Li, Feiyun Jiang, Yifan Mao

   pp. 231-239 · DOI: 10.5530/ijper.20271063 · 2026

   Objectives: To investigate the effect of baicalin on placental tissue injury in Preeclampsia (PE) rats and its possible mechanism. Materials and Methods: The caudal arterial blood pressure of Ed 1 5 and Ed 2 1 rats was d…

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3. Pueraria lobate Leaf Extract Inhibits the P13K/AKT and MAPK/STAT3/NF-κB Signaling Pathways on Lung Carcinoma Cells

   Jingjian Zhang, Ying Cui, Ling Yang, Yan Lv

   pp. 240-247 · DOI: 10.5530/ijper.20271514 · 2026

   Background: Lung Cancer (LC) is the foremost cause of worldwide cancer-related mortalities, principally, Non-Small Cell Lung Cancer (NSCLC). Pueraria lobata (PL) is a prominent traditional Chinese edible remedial plant t…

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4. Armepavine Ameliorates Acetaminophen-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammation

   Yanling Guo, Zhongting Pan

   pp. 248-256 · DOI: 10.5530/ijper.20273298 · 2026

   Objectives: The liver is an essential organ that plays a vital role in detoxification and protection against harmful chemicals and toxicants. Nursing care for patients with liver disorders needs a comprehensive understan…

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5. Exploring the Role of Proanthocyanidins in Mitigating Ulcerative Colitis in Mice

   Shaoqiang Sun, Yingde Wang

   pp. 257-265 · DOI: 10.5530/ijper.20271066 · 2026

   Aim: To determine the role of Proanthocyanidins (Pros) in mitigating Ulcerative Colitis (UC) in mice. Materials and Methods: A UC mouse model was constructed using dextran sulfate sodium induction in male adult Balb/c mi…

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6. Moringa oleifera Leaf Extract-Mediated Suppression of Epithelial to Mesenchymal Transition

   Samrat Paul, Anuradha Moirangthem, Nilanjana Ghosh, Sohini Sen, Sanjib Ray, Piyali Basak, Anupam Basu

   pp. 266-273 · DOI: 10.5530/ijper.20274154 · 2026

   Background: The increasing incidence of breast cancer remains a major global health challenge despite notable progress in diagnosis and therapy. Many patients progress to metastatic stages, where current treatments are n…

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7. Network Pharmacology and Molecular Docking Combined with in vitro α-Amylase and α-Glucosidase Assays to Assess Anti-diabetic Properties of Curcuma longa

   Xuan Liu, Minhua Tan, Yanling Ren, Yani Wang

   pp. 274-285 · DOI: 10.5530/ijper.20273728 · 2026

   Background: This study investigates the antidiabetic effects of Curcuma longa extract using in vitro enzyme assays, network pharmacology, and in silico molecular docking to elucidate its molecular mechanisms. Materials a…

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8. Rhazya stricta Targets Proliferation/Apoptosis/ Inflammation Axis in Osteoarthritis: A Comprehensive Network Pharmacology Based Experimental Validation Study

   Hui Xu, Qiuming Zhou, Jinming Lu, Hao Zhang

   pp. 286-297 · DOI: 10.5530/ijper.20272382 · 2026

   Background: Osteoarthritis (OA), a degenerative joint disorder, demands multi-target therapeutic strategies. Rhazya stricta, a traditional medicinal plant, was explored for its phytochemicals and their anti-OA potential.…

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9. Bacoside A Averts Oxidative Stress and Inflammation in Pulmonary Disease Induced by Cigarette Smoke in Rats Through NRF2/ATF4 and TLR4/NF-κB Signaling Pathways

   Lan Wang, Di Wang, Qingli Yao

   pp. 298-307 · DOI: 10.5530/ijper.20272482 · 2026

   Background: Chronic Obstructive Pulmonary Disease (COPD) has emerged as a foremost cause of worldwide illness. Exposure to Cigarette Smoke (CS) contributes to Oxidative Stress (OS) and inflammation, which is a chief caus…

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10. In silico and in vitro Evaluation of Microwave-Assisted Synthesized Isoxazole Chalcone Derivatives of Selected Phytoconstituents for Antidiabetic Activity

    Shubhangi Sutar, Radhika Shinde, Sachin Mali, Rachana Bhimanwar, Sandeep Patil, Sopan Nangare

    pp. 308-323 · DOI: 10.5530/ijper.20272380 · 2026

    Background: Diabetes is a major chronic health problem worldwide that has acquired significant attention from the scientific community. One approach to managing glucose synthesis and reducing the risk of diabetes is thro…

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11. Dapagliflozin-Induced Cardioprotection in Diabetic Cardiomyopathy Correlates with HMGB1-RAGE Axis Suppression

    Ting Zhang, Lizhu Zhang, Yanhua Zeng, Zhe Liao, Zihua Lu, Weini Chen

    pp. 324-330 · DOI: 10.5530/ijper.20275430 · 2026

    Background: Diabetic Cardiomyopathy (DCM) is a clinically important cardiac complication of Type 2 Diabetes Mellitus (T2DM). Its progression is closely related not only to chronic hyperglycemia and metabolic overload, bu…

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12. Design, Development, Impurity Characterization for Comprehensive Impurity Profiling in Eprosartan Mesylate by a Robust LC-MS/MS-Q-TOF Method: Emphasis on EPR-I, EPR-II, and Regio-Isomers

    Vasanth Pm, Swetha Sri Remidicherla, Atla Srinivasa Rao

    pp. 331-338 · DOI: 10.5530/ijper.20273045 · 2026

    Background: Eprosartan mesylate along side its related impurities, EPR-I, EPR-II, and their regioisomers, were simultaneously identified and quantified utilizing a sensitive and selective LC-MS/MS technique in conjunctio…

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13. Gastroprotective Activity of Dipsacoside B in Experimental Rats Against Ethanol-Induced Toxicity: Involvement of Antioxidant and Anti-Inflammatory Mechanisms

    Gaiyan Li, Yong Jiang

    pp. 339-347 · DOI: 10.5530/ijper.20272948 · 2026

    Background: Gastric ulcers, defined by lesions in the stomach lining, pose a considerable worldwide health issue with extensive ramifications in the gastrointestinal system. Effective nursing care is crucial in managing …

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14. Computational Annotation and Experimental Validation of Hypothetical Proteins as Novel Drug Targets in Klebsiella pneumoniae HS11286

    Yanping Li, Suresh Kumar, Lihu Zhang

    pp. 348-358 · DOI: 10.5530/ijper.20271889 · 2026

    Background: Klebsiella pneumoniae is a significant pathogen causing severe infections, especially among immunocompromised individuals. The emergence of Multidrug-Resistant (MDR) strains has heightened public health conce…

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15. Monotropein Inhibits Cell Growth and Induces Apoptosis in Breast Cancer MDA-MB-231 Cells

    Minxiang Wei, Minhua Xiao, Chaoyu Bi, Lu Yan, Lan Wang, Yujie Gu, Rui Gao

    pp. 359-367 · DOI: 10.5530/ijper.20274150 · 2026

    Background: Breast cancer, a complex disease marked by the unregulated growth of atypical cells, is the most widely diagnosed malignancy in women globally, profoundly affecting public health. Breast cancer generally affe…

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16. Glyphosate Exposure to Wistar Rats Develops Diabetic Nephropathy via Nrf2/ Keap-1 -Mediated Signalling

    Selvaraj Jayaraman, Shiny Paul, Manju Nallakandy Edakanambeth, Ponnulakshmi Rajagopal, Vishnu Priya Veeraraghavan, Ramya Murali

    pp. 368-380 · DOI: 10.5530/ijper.20273821 · 2026

    Background: Glyphosate (GLY), a widely used pesticide and endocrine disruptor, is frequently found in food and environmental sources. Long-term exposure may cause glucose resistance, the development of Type 2 Diabetes Me…

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17. Evaluation of in vitro Anti-Cancer Activity of Bunium persicum using NCIH-460, A375 and SK-N-SH Cancer Cell Line

    Shivali Sagar, Himanshu Joshi, Neha Joshi

    pp. 381-388 · DOI: 10.5530/ijper.20272827 · 2026

    Background: The purpose of this research is to determine if Bunium persicum have any anticancer effect when tested in vitro. However, scientists have not yet fully explored whether this drug can further help in cancer tr…

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18. Design, Synthesis, Characterization, in silico Studies and Biological Screening of Novel Triazole Coupled Amino Acid Derivatives

    Ravi Sankara Reddy Dontireddy, Pranav Chand Tadikonda, Madhuri Desavathu, Naga Divya Appari, Yaso Deepika Mamidisetti, Mounika Tummalapalli

    pp. 389-398 · DOI: 10.5530/ijper.20277197 · 2026

    Background: Triazoles produces a wide range of activities like anti-diabetic, anthelmintic, antimicrobial, anti-inflammatory and so on. The study aimed to synthesise triazole derivatives and assess their pharmacological …

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19. Analysis on the Active Components and Mechanisms of Action of Ecliptae Herba Intervention on Melanin Synthesis Applying UHPLC-Q-Orbitrap HRMS and Network Pharmacology in Combination with Molecular Docking Screening

    Mengyu Sun, Shuyu Guan

    pp. 399-410 · DOI: 10.5530/ijper.20271427 · 2026

    Background: White hair, a prevalent condition associated with melanin metabolism, has become increasingly common among the modern young population. Ecliptae Herba has been used since ancient time for white hair treatment…

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20. QbD Driven Method Development and Validation of Palbociclib by LC-MS/MS

    Sneha Thakur, Kavali Sai Varsha, Shankar Cheruku, Uzma Tahniyath, Mitta Chaitanya, B Chaitanya

    pp. 411-422 · DOI: 10.5530/ijper.20272262 · 2026

    Background: Palbociclib, an oral active cyclin dependent kinase inhibitor, is used in the treatment of metastatic breast cancer with narrow index and variable pharmacokinetics, hence the need of sensitive optimized analy…

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