Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation
1, 1, 1, 2, 2, 2
- 1C. U. Shah College Of Pharmacy, S. N. D. T. Women's University, Santacruz (W), Mumbai-400 049, India.
- 2Analytical Solutions, R-610, Rabale, M. I. D. C., Mumbai-400 701, India.
CORRESPONDENCE
Pratima A. Tatke
Professor, C.U. Shah College of Pharmacy, S.N.D.T Women's University, Mumbai-400049, India.
Received: 28-06-2012; Accepted: 28-03-2013.
Volume 47, Issue 2 · pp. 183-187 · 2013 · DOI:
ABSTRACT
The present study aims at development of method for simultaneous estimation of chloride and citrate in oral rehydration salt (ORS) by ion chromatography and its validation. The estimation was carried out with a step change gradient mode by altering concentrations of NaOH as an eluent, an anion exchange column IonPac AS11 analytical column, guard column AG11 and conductivity detector. The suppressor used was used as ASRS ULTRA. The developed method was validated as per ICH guidelines for various parameters. The method is useful for determining the contents of chloride and citrate in single run from ORS.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Kulkarni, P., Desai, S., Tatke, P., Ghule, T. P., Chavan, C., & Bhate, V. R. (2013). Simultaneous Estimation of Anions Present in Oral Rehydration Salt by ION Chromatography and its Method Validation. Indian Journal of Pharmaceutical Education and Research, 47(2), 183-187.
Copyright and licence
© 2013 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0