Solubility Enhancement of Satranidazole Using Self Emulsified Drug Delivery Systems
1, 1, 1, 2
- 1Department of Pharmaceutics, KLES College of Pharmacy Belagavi Karnataka-590010, INDIA.
- 2Department of Quality Assurance, KLES College of Pharmacy Belagavi Karnataka-590010, INDIA.
CORRESPONDENCE
Nitin Pandurang Gurav
Department of Pharmaceutics, KLES College of Pharmacy Belagavi Karnataka-590010, INDIA.
Received: 12-05-2015; Accepted: 13-02-2016.
Volume 50, Issue 2s (Supplement) · pp. s68-s75 · 2016 · DOI: 10.5530/ijper.50.2.20
ABSTRACT
Background: Satranidazole is an antiprotozoal and antibacterial drug which falls under class II drug as per biopharmaceutical classification systems having poor aqueous solubility.Aim: Therefore, present study was aimed at solubility enhancement of Satranidazole using self emulsified drug delivery system (SEDDS).Methods: SEDDS was prepared using Oleic acid as oil, Tween 20 and PEG400 as Surfactant and Co-surfactant respectively. For preparation of stable SEDDS, micro emulsion region was identified by constructing pseudo ternary phase diagram containing different proportion of surfactant: co-surfactant (1:1, 2:1 and 3:1), oil and water. Physico-Chemical Evaluation: Total nine SEDDS formulations were prepared (F-1 to F-9) and evaluated for self emulsification time & dispersibility, droplet size analysis, stability studies, turbidimetry, zeta potential, drug content and in vitro drug release.Results: Among all the formulations, three formulations (F-1, F-4 & F-7) showed a drug release of greater than 70% in 45 minutes whereas marketed preparation showed more than 70% of drug release in 90 minutes. Based on results of self emulsification time & dispersibility, droplet size analysis, drug content and in vitro drug release, F-7 formulation was selected as an optimized formulation which showed a maximum drug release of 94.89% in 45 minutes.Conclusion: Hence SEDDS formulations can be a potential alternative to traditional oral drug delivery systems of Satranidazole to improve its solubility.
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Gurav, N. P., Dandagi, P. M., Gadad, A. P., & Masthiholimath, V. S. (2016). Solubility Enhancement of Satranidazole Using Self Emulsified Drug Delivery Systems. Indian Journal of Pharmaceutical Education and Research, 50(2s), s68-s75. https://doi.org/10.5530/ijper.50.2.20
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