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Administration of Fresh Juice of Tinospora cordifolia Decreases Levels of Urinary Markers of Peroxisome Proliferator-Activated Receptors in Hyperlipidemic Patients

1, 1,2

  1. 1Department of Biochemistry, National Research Institute of Basic Ayurvedic Sciences, Pune, Maharashtra-411038, INDIA.
  2. 2Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana-124001, INDIA.

CORRESPONDENCE

Rajesh Dabur

Department of Biochemistry, National Research Institute of Basic Ayurvedic Sciences, Pune, Maharashtra-411038, INDIA.

rajeshdabur@yahoo.com

Received: 19-10-2015; Accepted: 14-03-2016.

Volume 50, Issue 3 · pp. 451-457 · 2016 · DOI: 10.5530/ijper.50.3.19

ABSTRACT

Objective: Tinospora cordifolia (Willd.) Miers juice (TCJ) is known for its anti-hyperlipidemic properties. This study was aimed to validate the efficacy of TCJ to activate PPARα in vivo in hyperlipidemic (HPL) patients.Materials and Methods: HPL (n=20) and healthy (n=22) volunteers were enrolled in the study. HPL patients were treated with TCJ for 14 days. The fasting urine and blood samples were collected on 0 and 14th day for analysis. The blood samples were used for biochemical analysis. Urine samples were subjected to LC-ESI-QTOFMS for the analysis of PPAR-α markers.Results: Treatment with TCJ depleted cholesterol (TC-24%), triglycerides (TG-28%) and low density lipoprotein (LDL- 14%) levels and increased high density lipoprotein (HDL) (p2.0 fold) after treatment with TCJ. The other biomarkers of HPL, ursodeoxycholic acid and chenodeoxycholic acid were also depleted (>4.0 fold) after TCJ treatment.Conclusion: The present data clearly depicted the regulatory effects of TCJ on the lipid metabolism. It emphasize that TCJ activates PPAR-α in vivo that decreased the urinary levels of PPARα biomarkers.

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    Shirolkar, A. R., & Dabur, R. (2016). Administration of Fresh Juice of Tinospora cordifolia Decreases Levels of Urinary Markers of Peroxisome Proliferator-Activated Receptors in Hyperlipidemic Patients. Indian Journal of Pharmaceutical Education and Research, 50(3), 451-457. https://doi.org/10.5530/ijper.50.3.19

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0