A Diterpenoid Taxoquinone from Metasequoia glyptostroboides with Pharmacological Potential
1, 1, 2, 1
- 1Department of Applied Microbiology and Biotechnology, School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, KOREA.
- 2Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbook 712-714, KOREA.
CORRESPONDENCE
Sun Chul Kang
Department of Biotechnology, College of Engineering, Daegu University, Gyeongsan, Gyeongbook 712-714, KOREA.
Received: 28-11-2015; Accepted: 05-03-2016.
Volume 50, Issue 3 · pp. 458-465 · 2016 · DOI: 10.5530/ijper.50.3.20
ABSTRACT
Background: The ubiquitin-proteasome pathway plays an important role in selective protein degradation and regulates multiple cellular processes, including cell cycle progression, proliferation and apoptosis. Cancer cells are more sensitive to the pro-apoptotic effects of proteasome inhibition than normal cells, hence, proteasome inhibitors can be used as novel anticancer drugs. Further, influenzacommonly known as “flu” is a contagious respiratory disease caused by sub-type of influenza A virus H1N1 which has resulted in enormous medical attention world-wide. Natural products are well known for their pharmacological potential in anticancer and antiviral therapies.Methods: In this study, an abietane-type diterpenoid, taxoquinone, isolated from Metasequoia glyptostroboides, was assessed for the first time for its therapeutic efficacy as a potential inhibitor of influenza A (H1N1) virus and 20S proteasomeusing cytopathic reduction assay and proteasome inhibition assay, respectively.Results: The taxoquinonedisplayed its anticancer effect in terms its ability to inhibit 20S human proteasome with IC50 value of 8.2 ± 2.4 μg/μL. Moreover, taxoquinone (500 μg/mL) displayed significant antiviral effect against H1N1 influenza virus in cytopathic reduction assay on MDCK cell line.Conclusion: These finding confirm pharmaceutical potential of taxoquinone as a novel therapeutic agent.
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Bajpai, V. K., Rather, I. A., Kang, S. C., & Park, Y. (2016). A Diterpenoid Taxoquinone from Metasequoia glyptostroboides with Pharmacological Potential. Indian Journal of Pharmaceutical Education and Research, 50(3), 458-465. https://doi.org/10.5530/ijper.50.3.20
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This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0