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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Synthesis, Evaluation and Molecular Docking Study of Some New 2-[(2,5-Disubstitutedanilino) Phenyl] Acetic Acid Derivatives

1, 2, 3, 2

  1. 1Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Hubli-580031, INDIA.
  2. 2Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Belgaum-580010, INDIA.
  3. 3State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing-210093, CHINA.

CORRESPONDENCE

Shashidhar Kerur

Deparment of Pharmaceutical Chemistry, Karnataka Lingayath Education University College of Pharmacy, Hubli-580031, INDIA.

shashi_kerur2002@yahoo.com

Received: 17-12-2015; Accepted: 24-04-2016.

Volume 50, Issue 3 · pp. 465-471 · 2016 · DOI: 10.5530/ijper.50.3.21

ABSTRACT

In the present study synthesis and antimicrobial activity of some new 2-[(2,5-disubstitutedanilino)phenyl]acetic acid derivatives 5a-f are described. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR, mass and elemental analysis. All compounds were screened for antitubercular and antimicrobial activity. Molecular modeling studies were performed to dock compounds into the ecKAS III binding site, which suggested probable inhibition mechanism. The results revealed that most of the compounds showed high to moderate biological activity against tested microorganisms.

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    Kerur, S., Alagawadi, K., Zhu, H., & Manvi, F. (2016). Synthesis, Evaluation and Molecular Docking Study of Some New 2-[(2,5-Disubstitutedanilino) Phenyl] Acetic Acid Derivatives. Indian Journal of Pharmaceutical Education and Research, 50(3), 465-471. https://doi.org/10.5530/ijper.50.3.21

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0