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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Preparation and in vitro and in vivo Evaluation of Chitosan-Gliclazide Mucoadhesive Microparticles by an Emulsification-Desolvation-Crosslinking Technique

1, 2, 3, 1

  1. 1School of Pharmacy, JNTUK College, Kakinada, Andhra Pradesh, INDIA.
  2. 2Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, INDIA.
  3. 3University College of Pharmaceutical Sciences, Acharya Nagarjuna University (ANU), Guntur, Andhra Pradesh, INDIA.

CORRESPONDENCE

Kora Pattabhi Rama Chowdary

Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, INDIA.

prof.kprchowdary@rediffmail.com

Received: 18-07-2018; Accepted: 26-07-2019.

Volume 53, Issue 4 · pp. 663-669 · 2019 · DOI: 10.5530/ijper.53.4.128

ABSTRACT

Introduction: Recently much emphasis is being laid on the development of microparticles because of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and predictable gastric emptying.Objective: The objective of the present study is to prepare and evaluate mucoadhesive microparticles of chitosan-gliclazide for oral controlled release.Methods: A new method namely emulsification-desolvation-crosslinking was used for the preparation of chitosangliclazide microparticles and the microparticles were evaluated by in vitro and in vivo methods.Results: Spherical chitosan-gliclazide microparticles could be prepared by the emulsification-desolvation-crosslinking method. The method was reproducible with regard to size and size distribution of the microparticles. The chitosan-gliclazide microparticles exhibited good muoadhesive property. Gliclazide release from the chitosan microparticles was slow and extended over longer periods of time and depended on the proportion of core: coat. Gliclazide release from the chitosan microparticles was by diffusion mechanism. Microparticles (F3) prepared using a core: coat ratio of 8:2 gave slow and controlled release of gliclazide over 12 hr similar to that of commercial gliclazide SR tablets. In the in vivo evaluation, the gliclazide microparticles (F3) gave a slower reduction in serum glucose levels and the reduced glucose levels were sustained over longer periods of time.Conclusion: Microparticles (F3) are considered as a promising microparticulate drug delivery system for oral controlled release of gliclazide over 12 hr for b.i.d administration.

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    Lakshmi, P. V., Chowdary, K. P. R., Rani, A. P., & Prasad, S. V. U. M. (2019). Preparation and in vitro and in vivo Evaluation of Chitosan-Gliclazide Mucoadhesive Microparticles by an Emulsification-Desolvation-Crosslinking Technique. Indian Journal of Pharmaceutical Education and Research, 53(4), 663-669. https://doi.org/10.5530/ijper.53.4.128

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0