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In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations

1,2, 3, 3, 3, 3

  1. 1Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
  2. 2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.
  3. 3Department of Pharmacy, Life Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka)-8100, BANGLADESH.

CORRESPONDENCE

Muhammad Torequl Islam

Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City-700000, VIETNAM.

muhammad.torequl.islam@tdtu.edu.vn

Received: 22-02-2019; Accepted: 04-09-2019.

Volume 53, Issue 4 · pp. 670-674 · 2019 · DOI: 10.5530/ijper.53.4.129

ABSTRACT

Background: Black seed oil and Phytol (PHY) are evident for their promising biological effects in various test systems.Aim: This study evaluates anti-atherothrombosis activity of Nigella sativa oil (NSO) and Phytol (PHY).Materials and Methods: The clotlysis activity of the NSO and/or PHY has been investigated by taking Streptokinase (SK) as a standard clotlysis drug.Results: The results suggest that the NSO and PHY exhibited a concentration-dependent clotlysis activity in human clotted blood. The highest clotlysis of the NSO and PHY was seen by 57.83 ± 0.23% and 53.05 ± 2.93% with 80 µL and 150 µg per tube, respectively. NSO co-treated with PHY showed a better clotlysis capacity than the NSO and PHY. The vehicle showed negligible clotlysis (2.86 ± 4.33%) capacity, while the standard SK (100 I.U.) showed 78.96 ± 1.08% clotlysis activity.Conclusion: NSO and/or PHY exhibited clotlysis activity in human clotted blood in in vitro.

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    Islam, M. T., Molla, S., Das, A. K., Zaman, F., & Khan, M. R. (2019). In vitro Anti-atherothrombosis Activity of Nigella sativa Oil, Phytol and their Combinations. Indian Journal of Pharmaceutical Education and Research, 53(4), 670-674. https://doi.org/10.5530/ijper.53.4.129

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0