Role of Testosterone in Swimming Exercise-induced Analgesia in Rats
1, 2, 2, 2, 3
- 1SGT College of Pharmacy, SGT University, Gurugram, Haryana, INDIA.
- 2Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
- 3All India Institute of Medical Sciences, Gautam Nagar, Ansari Nagar East, New Delhi, INDIA.
CORRESPONDENCE
Dheeraj Kumar Sharma
SGT College of Pharmacy, SGT University, Gurugram, Haryana, INDIA.
Received: 27-02-2019; Accepted: 26-07-2019.
Volume 53, Issue 4 · pp. 675-681 · 2019 · DOI: 10.5530/ijper.53.4.130
ABSTRACT
Objective: “Feel good effect” of exercise is well known. Activation of pain inhibitory mechanisms after exercise is also well documented. Swimming is considered as a beneficial exercise as well as health-promoting sport. The significance of testosterone in swimming exercise-induced analgesia is yet to be understood. Therefore, it is worthwhile to investigate the significance of testosterone in swimming exercise-induced analgesia.Materials and Methods: The basal tail flick latencies of all animals were recorded by using tail flick analgesiometer. In order to observe the effect of testosterone on swimming exercise-induced analgesia, testicles of animals of some groups were surgically removed. Then animals were subjected to swimming sessions of different patterns. After swimming, tail flick latencies were measured.Results: Swimming sessions resulted in increase in pain thresholds of all animals. Castration negatively affected the degree of analgesia achieved in rats. However, daily treatment of testosterone propionate (500µg/kg, s.c.) improved swim-induced analgesia in castrated rats. Moreover, daily administration of naloxone hydrochloride (1mg/kg, i.p.) fifteen min prior to swimming suppressed testosterone therapy resulted in an increase in swim-induced analgesia in castrated animals.Conclusion: We concluded that testosterone plays a significant role in swimming exercise-induced analgesia in male Wistar albino rats and this positive effect of testosterone on pain threshold might be mediated through its probable effect on the endogenous opioid system.
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Sharma, D. K., Singh, N. K., Goyal, A., Gupta, J. K., & Yadav, H. N. (2019). Role of Testosterone in Swimming Exercise-induced Analgesia in Rats. Indian Journal of Pharmaceutical Education and Research, 53(4), 675-681. https://doi.org/10.5530/ijper.53.4.130
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