Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis
1, 2, 3
- 1Department of Bao’s Orthopedic, Inner Mongolia International Mongolian Hospital, Hohhot City, Inner Mongolia, CHINA.
- 2Department of Emergency, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe Road, Zhengzhou City, Henan, CHINA.
- 3Department of Rheumatology, XuZhou Central Hospital, XuZhoucity, JiangSu Province, CHINA.
CORRESPONDENCE
Meirong Li
Department of Rheumatology, XuZhou Central Hospital, XuZhoucity, JiangSu Province, CHINA.
Received: 01-08-2020; Accepted: 30-01-2021.
Volume 55, Issue 2 · pp. 507-516 · 2021 · DOI: 10.5530/ijper.55.2.89
ABSTRACT
Background: Rosmarinus officinalis L. (family Lamiaceae is a perennial herb or small woody evergreen tree, commonly known as rosemary, which is native to the Mediterranean and Asia and reasonably hardy in cool climates. It has been used as a decoction in traditional Unani and Swedish medicine for the treatment of inflammatory diseases.Aim: To isolate rosmarinic acid (RA) from R. officinalis. leaf extract and to evaluate its protective effects against Freund’s adjuvant-induced arthritis in rats.Materials and Methods: Arthritis was induced via sub-plantar injection of 1mg heat-killed Mycobacterium tuberculosis (complete Freund’s adjuvant, CFA) into the left hind paw of rats. The experiment was designed and optimized based on published methods.Results: At 60 mg/kg, the RA fraction of the methanolic extract of R. officinalis L. exerted potentially effective anti-arthritic effects by controlling inflammation in an adjuvant-induced experimental model.Conclusion: Considering experimental findings relating to pharmacological and biochemical parameters, we conclude that oral administration of the RA fraction (30 and 60 mg/kg) from the methanolic extract of R. officinalis L. exerts anti-arthritic effects and controls inflammation in an adjuvant-induced arthritis rat model. RA is therefore a promising plant-derived anti-arthritic agent for the treatment of inflammatory disorders.
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Wei, T., Liu, Y., & Li, M. (2021). Anti-inflammatory and Anti-arthritic Activity of Rosmarinic acid Isolated from Rosmarinus officinalis in an Experimental Model of Arthritis. Indian Journal of Pharmaceutical Education and Research, 55(2), 507-516. https://doi.org/10.5530/ijper.55.2.89
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