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A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

1, 2,3, 4

  1. 1Department of Pharmaceutics, Girijananda Chowdhury Institute of Pharmaceutical Science, Girijananda Chowdhury University, Dekargaon, Tezpur, Sonitpur, Assam, INDIA.
  2. 2Department of Pharmacy, Assam Science and Technology University, Jalukbari, Guwahati, Assam, INDIA.
  3. 3Department of Pharmacology, NETES Institute of Pharmaceutical Science, Mirza, Guwahati, Assam, INDIA
  4. 4Department of Roga Nidan, Govt. Ayurvedic College and Hospital, Sundarbari, Jalukbari, Guwahati, Assam, INDIA.

CORRESPONDENCE

Mr. Purbajit Chetia

Department of Pharmacy, Assam Science and Technology University, Jalukbari, Guwahati-781013, Assam, INDIA.

purbajit.chetia@gmail.com

Received: 16-02-2023; Accepted: 22-05-2024.

Volume 58, Issue 3 · pp. 709-721 · 2024 · DOI: 10.5530/ijper.58.3.79

ABSTRACT

Background: Rheumatoid Arthritis (RA) is a chronic form of inflammatory disorder where the immune system causes the destruction of bones and cartilage in joints and impacts the quality of life. Few studies have explored the possibility of the involvement of oxidative stress markers in the pathophysiological process of disease progression in RA as well as the beneficial effect of antioxidants. It was discovered that no systematic review had been carried out to support this idea over the previous five years.Aim: This review is intended to analyse the participation of oxidative stress markers in the origination and development of RA so that they can be a potential biomarker for supportive therapy.Materials and Methods: This systematic review was carried out as per the PRISMA guidelines. The authors executed a systematic literature search in different search engines for cross-sectional case-control research studies during the period from January 1, 2018 to November 30, 2022. Following inclusion and exclusion criteria, 16 articles have been selected for final analysis.Results: The evaluated biomarkers in the aforementioned studies countenance the participation of oxidative stress in RA with disease progression. However, additional research will be needed in the future to determine how oxidative stress contributes to the progression of RA and the potential role of antioxidants.Conclusion: Oxidation biomarkers may be an important tool in the early diagnosis of RA starting at the preclinical stage as well as in determining how the disease is evolving, offering new promise for employing these biomarkers as a focal point for supportive therapy.

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    Ahmed, A. B., Chetia, P., & Kalita, H. (2024). A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies. Indian Journal of Pharmaceutical Education and Research, 58(3), 709-721. https://doi.org/10.5530/ijper.58.3.79

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    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0