Volume 58, Issue 3

Research Article

1. QSAR Based Drug Repurposing: A New Paradigm in Breast Cancer Research

   Rajaram Mohapatra, Pratikeswar Panda, Sudhansu Sekhar Rout

   pp. 695-708 · DOI: 10.5530/ijper.58.3.78 · 2024

   Breast carcinoma is the world’s most prevalent type of cancer.The building of predictive cytotoxicity breast cancer models assists permanent synthetic activities and give critical information about structure-activity of …

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2. A Systematic Review on Association of Oxidative Stress in Rheumatoid Arthritis Based on Cross-Sectional Case-Control Studies

   Abdul Baquee Ahmed, Purbajit Chetia, Hemen Kalita

   pp. 709-721 · DOI: 10.5530/ijper.58.3.79 · 2024

   Background: Rheumatoid Arthritis (RA) is a chronic form of inflammatory disorder where the immune system causes the destruction of bones and cartilage in joints and impacts the quality of life. Few studies have explored …

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3. Methodology and Results Analysis of Effect and Economic Evaluations Related to Pharmaceutical Care Practice in China: A Recent Review

   Chunyan Wei, Ruofei Li, Zhiang Wu, Guirong Xiao, Ming Hu

   pp. 722-729 · DOI: 10.5530/ijper.58.3.80 · 2024

   Background: To evaluate the value of pharmaceutical care, and sort out the existing problems in the current researches. Materials and Methods: We established the research strategy and searched seven databases. Two review…

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4. Tablet Compression Optimization of Ivabradine Sustained-Release Tablet Using Full Factorial Design

   Kang Min Kim, Shugeng Cao, Jae Sung Pyo

   pp. 730-735 · DOI: 10.5530/ijper.58.3.81 · 2024

   Aim: This study aimed to qualitatively identify the ranges of the factors involved in the tablet compression process for ivabradine Sustained Release (SR) tablets. Materials and Methods: A full factorial design of experi…

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5. A Novel Targeted Nanoliposomal Atorvastatin Transdermal Patch Assisted with Solid Microneedles for Improved Bioavailability

   Sai Ramya Srikakulam, Jyothirmayee Devineni, Chandana Mokkapati, Yaswanth Venigalla, Aparna Pothuri, Anuhya Acchi, Sushil Sharma

   pp. 736-750 · DOI: 10.5530/ijper.58.3.82 · 2024

   Objectives: The present study investigated the alternate route of delivery to avoid first pass metabolism and to increase bioavailability by nanosized Liposomes (LP) with Microneedles (MNs) Assistance for the Delivery of…

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6. Design and Characterization of Timolol Loaded Gellan Gum Nanoparticles for Improved Ocular Drug Delivery

   Gurpreet Kandav, Anjali Kumari Lochab, Tamanna Sharma

   pp. 751-759 · DOI: 10.5530/ijper.58.3.83 · 2024

   Aim: Glaucoma treatment often involves the topical application of Timolol maleate (TM) to the eye. However, achieving the desired bioavailability via the ocular route can be challenging due to poor retention and penetrat…

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7. The Development, Formulation, and Assessment of Polyelectrolytic Complexes of an Anticancer Compound (Vinorelbine Tartarate)

   Maged Mohammed Abdo Mohsen, K. Nagasree, Amit B. Patil

   pp. 760-770 · DOI: 10.5530/ijper.58.3.84 · 2024

   Introduction: Vinorelbine tartrate is used as a first-line treatment in conjunction with conventional treatments, especially advanced disease including cancer patients. Objectives: The objective of the study was to devel…

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8. Fabrication of Biocompatible Transdermal Nanofibrous Patch for Localized Delivery of Lidocaine and Rosemary Oil to Improve Effective Management of Lymphoma Pain and Nursing Care

   Yanjing Guo, Ningning Li, Xingyu Chen, Tao Wang, Wenping Zhang, Lihua Wu

   pp. 771-783 · DOI: 10.5530/ijper.58.3.85 · 2024

   Background: The primary goal of the current investigation is to fabricate a transdermal NFs patch-based drug delivery system using Poly-N-Vinyl Caprolactam (PNVCL) blended with sodium alginate to prepared transdermal nan…

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9. Development of Nanosponge Formulations of Rosuvastatin for Oral Delivery Using a Central Composite Design

   Sadhana Noothi, Narender Malothu, Vishnu Pulavarthy, BVS Praveen

   pp. 784-793 · DOI: 10.5530/ijper.58.3.86 · 2024

   Background: Rosuvastatin (ROS) is an anti-hyperlipidaemic drug which reduces cholesterol levels, having poor solubility and low bioavailability (<20%). The objective of the present study was to increase ROS bioavailabili…

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10. Comparison of Normal saline, Activated Charcoal and Intravenous Lipid Emulsion in a Rat Model of Colchicine Overdose: Experimental Study

    Mustafa Ferudun Çelikmen, Sezgin Sarikaya, Doğaç Niyazi Özüçelik, Fadime Canbolat, Engin Sümer, Elif Çiğdem Keleş, Deniz Sema Maktav Çelikmen

    pp. 794-801 · DOI: 10.5530/ijper.58.3.87 · 2024

    Aim: The aim of this study is to investigate the effects of Normal Saline (NS), Activated Charcoal (AC) and Intravenous Lipid Emulsion (ILE) in colchicine poisonings that resulted in death. Study Design: The research is …

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11. Inhibiting Cancer Progression through Targeting HDAC2 with Novel Ligands: A Dynamic Insights through Virtual Screening and Simulation

    Ayyub Ali Patel, Hani Alothaid, Ayaz Khurram Mallick, Adel Ibrahim Alalawy, Rasha Tarek Mirdad, Mahmoud Tarek Mirdad, Mohammed Tarek Mirdad, Marya Ahsan, Mohammed Tarique

    pp. 802-813 · DOI: 10.5530/ijper.58.3.88 · 2024

    Background: Cancer is a multifaceted disease characterized by uncontrolled cell growth and represents a significant global health challenge. The intricate origins of cancer involve various factors that may act independen…

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12. METTL14-Mediate the Biological Effects of EMT in Bladder Cancer Cells by Methylating SOX4 mRNA with m6A

    Mengliang Xie, Huantao Zhang

    pp. 814-821 · DOI: 10.5530/ijper.58.3.89 · 2024

    Objectives: Bladder Cancer (BC) is one of the most common malignant tumours of urinary system, with high rates of metastasis and mortality. Methyltransferase-like 14 (METTL14) is an RNA N6-adenosine methyltransferase tha…

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13. Effects of Bifidobacterium Quadruple Viable Tablets Combined with Immune-Enhancing Enteral Nutritional Adjuvant Therapy on Intestinal Flora, Intestinal Mucosal Barrier and Immune Function in Elderly Patients with Hepatitis B Cirrhosis

    Mengmeng Xing, Chuanshun Xiao, Xiangzhong Liu Yongmei Wang

    pp. 822-829 · DOI: 10.5530/ijper.58.3.90 · 2024

    Objectives: Hepatitis B cirrhosis is a serious condition caused by the hepatitis B virus, leading to liver fibrosis and vascular proliferation. Current clinical treatments still have limitations, prompting interest in mi…

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14. Anticancer and Hepatoprotective Role of Selenium Nanoparticles against Liver Carcinogen Acrylamide Induced Toxicity: In vitro and in vivo Studies

    Uzma Faridi, Nahla Zidan, Hebbatallah Atteia, Yahya Al-Awthan, Adel I Alalawy, Md. Qussen Akhtar, Mohamed Sakran, Humaira Parveen

    pp. 830-836 · DOI: 10.5530/ijper.58.3.91 · 2024

    Background and Objectives: Selenium is considered one of the essential components of many enzymes, particularly the antioxidant enzymes such as thioredoxin reductase. Vegetables, among other food sources, are common sour…

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15. Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents

    Vaibhav Gawade, Vitthal Chopade

    pp. 837-853 · DOI: 10.5530/ijper.58.3.92 · 2024

    Background: The biological activity of thiophene and carbohydrazide derivatives is well known; some of them are included in various anticancer drugs. Objectives: The main goal of this work was to develop effective, effec…

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16. Lithotriptic Effect of Cinnamomum verum and Nigella sativa on Ureteric Calculi

    Mrinal Sanaye, Nikhat Khan, Dinesh Dhodi, Saleha Parveen

    pp. 854-860 · DOI: 10.5530/ijper.58.3.93 · 2024

    Introduction: Urolithiasis is one of the most prevailing diseases in the society. Conventional treatments are symptomatic and are not targeted to direct the dissolution of ureteric calculi. Thus, in this study plants lik…

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17. Plumbago indica L. Root Extract Induces Anti-proliferation, Anti-migration and Apoptosis on the Human Lung Cancer Cell Line

    Wichuda Phiphitphibunsuk, Benjaporn Buranrat

    pp. 861-869 · DOI: 10.5530/ijper.58.3.94 · 2024

    Background: Plumbago indica L. (PI) is a Thai traditional medicine that has been reported to improve health benefit including anticancer property. Nevertheless, the effects of PI and this mechanism are still less data in…

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18. Headspace SPME-GC-MS Analysis and in silico Molecular Docking Studies of Phytochemical Compounds Present in Houttuynia cordata Thunb

    Thokchom Biona, Nameirakpam Bunindro Singh, Ojit Singh Keithellakpam, Sanjai Srinivasan, Shankarrao Patil, Pulok Kumar Mukherjee, Nanaocha Sharma

    pp. 870-881 · DOI: 10.5530/ijper.58.3.95 · 2024

    Aim: The study aimed to identify the phytochemical constituents present in the leaves, stems, and roots of H. cordata and perform in silico molecular docking studies of selected common compounds present in all three part…

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19. Protective Effect of Saikosaponin D against Streptozotocin-Induced Diabetic Nephropathy in Rats by Regulating the Oxidative Stress and Inflammatory Markers

    Yan Chen, Guanglu Zhang, Rijing Liang, Yao Shen, Xia Jiao

    pp. 882-889 · DOI: 10.5530/ijper.58.3.96 · 2024

    Background: Diabetic Nephropathy (DN) is a common problem in diabetes and is characterized by glomerular dysfunction, hyperfiltration, and ultimately kidney failure. Objectives: The present study was intended to understa…

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20. An Umbelliferone-induced Caspase-Mediated Apoptosis in MDA-MB-231 Breast Cancer Cells

    Mohammed Albratty, Hafiz A Makeen

    pp. 890-898 · DOI: 10.5530/ijper.58.3.97 · 2024

    Background: A highly malignant tumor, Breast Cancer (BC) has a poor prognosis for patients with the highest mortality rates in women. BC is currently treatable with a limited number of therapeutic strategies. Aim: Natura…

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