Azadirachta indica Fruit Mucilage Aided Mucoadhesive Microspheres of Acyclovir for Drug Entrapment and Mucoadhesive Time Assets with Design-Expert Software
1, 1, 2
- 1Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamil Nadu, INDIA.
- 2Department of Pharmaceutics, RR College of Pharmacy, Chikkabanavara, Bangalore, Karnataka, INDIA.
CORRESPONDENCE
Hindustan Abdul Ahad
Department of Pharmaceutics, RR College of Pharmacy, Chikkabanavara, Bangalore-90, Karnataka, INDIA.
Received: 22-11-2023; Revised: 02-03-2024; Accepted: 15-07-2024.
Volume 59, Issue 1s (Supplement) · pp. s243-s255 · 2025 · DOI: 10.5530/ijper.20256428
ABSTRACT
Introduction: Mucoadhesive microspheres for drug delivery are retained in the stomach for an extended period for localized drug release and effect.Objectives: This research aims to explore the mucoadhesive properties of Azadirachta indica fruit mucilage when incorporated into mucoadhesive microspheres, utilizing Acyclovir as a model drug.Materials and Methods: Employing a Box Behnken design, 13 formulations of microspheres were developed, varying Azadirachta indica Mucilage (AIFM) levels, carbomer 934P and stirring speed. Design Expert software was used to assess the impact of these factors on entrapment efficacy and mucoadhesion time. Congeniality studies involved the examination of microspheres for Acyclovir content and discharge.Results: Results indicated that Acyclovir entrapment increased with higher AIFM levels and mucoadhesion time was prolonged in formulations with elevated AIFM levels. The optimal stirring speed was determined to be 750 rpm.Conclusion: The study concludes that Acyclovir demonstrates effective stomach-specific drug delivery through carbomer 934P, further enhanced by Azadirachta indica fruit mucilage, particularly at a stirring speed of 750 rpm in the formulation of mucoadhesive microspheres.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Babu, G. N., Menaka, M., & Ahad, H. A. (2025). Azadirachta indica Fruit Mucilage Aided Mucoadhesive Microspheres of Acyclovir for Drug Entrapment and Mucoadhesive Time Assets with Design-Expert Software. Indian Journal of Pharmaceutical Education and Research, 59(1s), s243-s255. https://doi.org/10.5530/ijper.20256428
Copyright and licence
© 2025 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0