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Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window

1, 1, 1, 1, 1, 2, 2, 1, 1,5,6, 3, 4, 1

  1. 1Department of Pharmaceutical Chemistry, BVDU's Poona College of Pharmacy, Paud Road, Erandwane, Pune, Maharashtra, INDIA.
  2. 2Department of Pharmacology, BVDU's Poona College of Pharmacy, Paud Road, Erandawane, Pune,, Maharashtra, INDIA.
  3. 3Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.
  4. 4Department of Pharmacognosy, BVDU's Poona College of Pharmacy, Paud Road, Erandawane, Pune,, Maharashtra, INDIA.
  5. 5Department of Entomology, University of California, Davis, One Shields Ave, Davis, California, USA.
  6. 6UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, California, USA.

CORRESPONDENCE

Dr. Ravindra Kulkarni

Department of Pharmaceutical Chemistry, BVDU's Poona College of Pharmacy, Erandawane, Pune-411038, Maharashtra, INDIA.

ravigk2000@gmail.com

Received: 03-09-2023; Revised: 15-10-2024; Accepted: 22-01-2025.

Volume 59, Issue 2 · pp. 453-471 · 2025 · DOI: 10.5530/ijper.20255143

ABSTRACT

Aim: Isocitrate lyase is the ancient glyoxylate cycle enzyme that catalyzes isocitrate cleavage into succinate and glyoxylate. The glyoxylate cycle is a key metabolic pathway as indicated by significant data on many host pathogens, which confirm the fundamental existence, in particular, causing life-threatening diseases, including tuberculosis.Objectives: Mycobacterium tuberculosis Isocitrate lyase and other organisms, which express ICL, have attracted the attention of molecular biologists and medicinal chemists due to their indispensable role in normal cellular metabolic pathways and even resistance. Numerous studies that blocked genes expressing ICL and gene knockout in experimental animals indicated retarded growth. The origins of these inhibitor studies approaches are categorized into mycobacterial and non-mycobacterial Isocitrate lyases.Conclusion: Nonetheless, these inhibitors can be either synthetic or natural, while in this study, the authors emphasize catalytic enzyme information of Isocitrate lyase.

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    Khanojia, G., Walhekar, V., Ashwini, P., Birajdar, P., Ritesh, P., Muthal, A., Bodhankar, S., Bagul, C., Kumar, D., Macha, B., Shinde, V., & Kulkarni, R. (2025). Deciphering Molecular Insights into Isocitrate Lyase and their Inhibitors: A Detailed Display through Medicinal Chemistry Window. Indian Journal of Pharmaceutical Education and Research, 59(2), 453-471. https://doi.org/10.5530/ijper.20255143

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0