Formulation, Optimization and Evaluation of Naringenin Loaded Cubosomes for Effective Management of Alzheimer's Disease
1, 1, 1, 1, 1
- 1Department of Pharmaceutics, KLE College of Pharmacy-Belagavi, KLE Academy of Higher Education and Research (KAHER), Nehru Nagar, Belagavi, Karnataka, INDIA.
CORRESPONDENCE
Kishori Prasanna Sutar
Department of Pharmaceutics, KLE College of Pharmacy-Belagavi, KLE Academy of Higher Education and Research (KAHER), Nehru Nagar, Belagavi, Karnataka, INDIA.
Received: 29-11-2024; Revised: 15-01-2025; Accepted: 03-06-2025.
Volume 59, Issue 4 · pp. 1305-1311 · 2025 · DOI: 10.5530/ijper.20251264
ABSTRACT
Objectives: The goal of this work was to formulate a stable naringenin-loaded cubosomal in situ gel to improve naringenin absorption into the brain by direct nose-to-brain transfer.Materials and Methods: This investigation aimed to prepare, optimize and evaluate a cubosomal in situ gel containing naringenin, aimed at facilitating the delivery of the drug to the brain via nasal administration. Cubosomes were fabricated using a top-down methodology and optimization was conducted using 32 factorial designs. Cubosomes were analyzed for particle size, encapsulation efficiency, zeta potential and cumulative percent drug release. Poloxamer-407 was used as a thermoreversible and mucoadhesive polymer for preparing naringenin-loaded cubosomal in situ gel.Results: The optimized cubosome formulation (F3) containing 3% Glyceryl Monooleate (GMO) and 1.5% poloxamer, exhibited a particle size of 123.2 nm, an encapsulation efficiency of 71.12% and a zeta potential of -38.61. The Transmission Electron Microscopy (TEM) image represented the smooth cubic structure of naringenin-loaded cubosomes. The thermoreversible in situ gel demonstrated appropriate gelation temperatures, viscosities, pH levels and in vitro drug diffusion characteristics. The in vitro drug diffusion study revealed a higher percentage cumulative drug release, reaching 82.21%.Conclusion: The results obtained demonstrated enhanced capability of the developed naringenin-loaded cubosomes to facilitate drug permeation through the nasal cavity.
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Raut, Y., Sutar, K. P., Hooli, S., Naik, G., & Udagatti, V. (2025). Formulation, Optimization and Evaluation of Naringenin Loaded Cubosomes for Effective Management of Alzheimer's Disease. Indian Journal of Pharmaceutical Education and Research, 59(4), 1305-1311. https://doi.org/10.5530/ijper.20251264
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