Volume 50, Issue 4

Original Article

1. Assessment of Attitudes of Cuban University Pharmacy Students Toward Pharmaceutical Care

   Alina de las Mercedes Martinez Sanchez, Abdel Bermúdez del Sol

   pp. 504-511 · DOI: 10.5530/ijper.50.4.1 · 2016

   Objective: To describe the attitude of Cuban pharmacy students toward pharmaceutical care. Methods: This study is a descriptive approach to the standard Pharmaceutical Care Attitudes Survey among professional fourth year…

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2. Objective Structured Clinical Examination in Undergraduate Pharmacy Students: Time to Switching to an Alternative Exam for Clerkship Courses

   Sarah Mousavi, Mohammdreza Amirsadri

   pp. 512-516 · DOI: 10.5530/ijper.50.4.2 · 2016

   Background: Significant changes in the clinical context of health professional education and impressive body of research on the measurement of clinical competence support the use of the Objective Structured Clinical Exam…

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3. Evaluation of the E-Learning Program Impact over Organizations in the Romanian Pharmaceutical Industry

   Petruţa Blaga, Manuela Rozalia Gabor

   pp. 517-529 · DOI: 10.5530/ijper.50.4.3 · 2016

   This research aims to measure the impact of some initiatives within the human resources over an organization, market leader in the pharmaceutical field, the measurement of efficiency concerning the business education pro…

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4. Teaching Reform of Pharmaceutical Chemistry with PBL Method

   Xiangling Gu, Xinfeng Song, Hanwen Sun, Maojiang Dong, Jing Li, Guiyun Liu, Zhiqin Zhang, Jiwei Wu

   pp. 530-533 · DOI: 10.5530/ijper.50.4.4 · 2016

   Objective: Pharmaceutical chemistry plays a key role in pharmaceutical speciality, which is aiming at making students master basic concepts, basic theory and basic skills of pharmaceutical chemistry. The teachers, howeve…

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5. Developing an Outcome-Based Pharmaceutical Science Curriculum: an Evaluation Based on Triangulation Method

   Khor Poh Yen, Mahendran Sekar, Mohammed Tahir Ansari

   pp. 534-541 · DOI: 10.5530/ijper.50.4.5 · 2016

   Pharmacy education in Malaysia is aiming in producing and developing pharmacists who are clinical-based and competent in the tasks related to clinical pharmacy. Since a workforce that is well-trained to function in the i…

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6. Present Status of Pharmacy Education and Practice in Angola: Trends and Challenges

   Alina de las Mercedes Martínez Sánchez

   pp. 542-548 · DOI: 10.5530/ijper.50.4.6 · 2016

   Pharmacy education in Angola, the second largest sub-Saharan country after the Demo cratic Republic of Congo, has undergone some changes since the first pharmacy school was established in 2001. Currently, to practice as …

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7. Dissolution Rate Enhancement of Entacapone and Formulation of its Oro- Dispersible Tablets: Applying Statistical Design

   Mahapatra Anjan Kumar, Padala Narasimha Murthy, Nagampalli Haritha Sameeraja, Palei Narahari Narayan

   pp. 549-562 · DOI: 10.5530/ijper.50.4.7 · 2016

   The major aim of the study was to enhance the solubility and dissolution rate of entacapone by complexation with cyclodextrins (β-CD/HP β-CD). Further the selected cyclodextrin complexes are deigned to formulate oro-disp…

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8. A Novel QbD Based SPE-HPLC Bio-analytical Method for Edaravone in Rat Plasma, A Pharmacokinetic Study

   Suraj Fanse, Madhuri Baghel, Prachi Bhamre, Sadhana Rajput

   pp. 563-573 · DOI: 10.5530/ijper.50.4.8 · 2016

   A simple, sensitive and feasible Quality by design based RP-HPLC bioanalytical method was developed and validated for Edaravone. Plackett burman design and 3¥3 full factorial designs were utilized for factor screening an…

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9. Identification of novel drug candidate against Mycobacterium Tuberculosis InhA protein through Computer aided drug discovery

   Nisha T. Nair, Shefin Nisthar, Bindu A. Sunil kumar

   pp. 574-582 · DOI: 10.5530/ijper.50.4.9 · 2016

   Tuberculosis is a common and often deadly infectious disease caused by Mycobacteria. WHO estimates that around eight million people are suffering from tuberculosis every year. The Administration of antibiotics fails due …

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10. Inhibition of hesperidin on epithelial to mesenchymal transition of non-small cell lung cancer cells induced by TGF

    Hai-bin Yu, LI Li, Zhou-xin Ren, Jun-ling Shen

    pp. 583-590 · DOI: 10.5530/ijper.50.4.10 · 2016

    Transforming growth factor-β1 (TGF-β1) is a known potent inducer causing epithelial to mesenchymal transition(EMT) in some cancers. The present study was to evaluate the effect of hesperidin on EMT of non-small cell lung…

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11. Synthesis and Antimalarial Activity Evaluation of Some Mannich Bases of Tetraoxane-Phenol Conjugate

    Gogoi Jinky, Chetia Dipak, Kumawat Kumar Mukesh, Rudrapal Mithun

    pp. 591-598 · DOI: 10.5530/ijper.50.4.11 · 2016

    A new series of seven Mannich bases of tetraoxane-phenol conjugate as possible antimalarial compounds were synthesized and evaluated in vitro for their antimalarial activity. All the synthesized compounds exhibited good …

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12. Schiff’s base derivatives of murrayanine demonstrated enhanced anti-oxidant activity than its parent moiety

    Ruchi S. Shivhare, Debarshi Kar Mahapatra, Rajani R. Nair, Swati N. Deshmukh

    pp. 598-604 · DOI: 10.5530/ijper.50.4.12 · 2016

    Objective: Free radicals like superoxide anion radical (O2.-), hydroxyl radical (HO.), alkyl radical (R.), alkoxy radical (RO.), peroxy radical (ROO.) and nitric oxide radical (NO.) often leads to oncogenic proliferation…

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13. Rosuvastatin Loaded Nanostructured Lipid Carrier: For Enhancement of Oral Bioavailability

    Anand Panchakshari Gadad, Swetha Gangadhar Tigadi, Panchaxari Mallappa Dandagi, Vinayak Shivamurthi Mastiholimath, Uday Baburao Bolmal

    pp. 605-611 · DOI: 10.5530/ijper.50.4.13 · 2016

    Rosuvastatin is a lipid lowering agent, which has low solubility and low bioavailability of 20% with oral administration. Therefore the present study was undertaken to improve solubility and bioavailability of Rosuvastat…

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14. Picogram Level Quantification of Grazoprevir and Elbasvir with Deuterated Internal Standards in Human Plasma Samples by LC–ESI-MS/MS

    Haritha Potluri, Sreenivasa Rao Battula, Sunandamma Yeturu

    pp. 612-619 · DOI: 10.5530/ijper.50.4.14 · 2016

    A fixed oral dose combination of grazoprevir and elbasvir is used for the treatment of patients with genotypes 1&4 HCV infections. In this manuscript, authors developed a simple, sensitive and specific liquid chromatogra…

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15. Evaluation of Antioxidant, Toxicological and wound healing Properties of Hibiscus rosa-sinensis L. (Malvaceae) ethanolic leaves extract on different Experimental animal models

    Sumanta Mondal, Debjit Ghosh, Nuni Sagar, Seru Ganapaty

    pp. 620-637 · DOI: 10.5530/ijper.50.4.15 · 2016

    Objective: The present research article was conducted to study the toxicity profile, antioxidant potential and wound healing activity of ethanolic leaves extract of Hibiscus rosa-sinensis L. (ELEHR). Materials and Method…

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16. Anti-inflammatory screening of ethanolic leaf extract of Vernonia arborea Buch. –Ham.in formalin induced albino wistar rats

    Sriram Sridharan, Meenaa Venkatramani, Kavitha Janakiraman, Brindha Pemiah, Sasi kumar Chinnagounder

    pp. 638-648 · DOI: 10.5530/ijper.50.4.16 · 2016

    Context: The therapeutic potential of the genus Vernonia has been well documented over the years. However the pharmacological potential of the plant Vernonia arborea (Asteraceae) has been relatively less explored. Object…

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17. Protective Effects of -3 fatty acids and/ or Nano- selenium on Cisplatin and Ionizing radiation induced liver toxicity in rats

    Hanan A Fahmy, Afrag Sh Abd El Azim, Ola A Gharib

    pp. 649-656 · DOI: 10.5530/ijper.50.4.17 · 2016

    Cisplatin (CP) and/ or radiation exposures cause oxidative stress, which induced liver toxicity. The present study was undertaken to explore if fish oil (FO) and /or selenium nano particles (SeNPs) can minimize CP-induce…

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18. HPTLC Method Development and Validation of Antidiabetic Marker Compound from Polyherbal Formulation

    Shrikrishna Madhukar Nandanwadkar, Vinayak Shivamurthi Mastiholimath, Soniya Ramdas Surlaker

    pp. 657-664 · DOI: 10.5530/ijper.50.4.18 · 2016

    The objective of this research work was to develop a simple, rapid and reliable HPTLC method for standardization of anti-diabetic polyherbal formulation and to carry out validation of Trigonelline in formulation. Develop…

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19. Hydroxypropyl β-Cyclodextrin (HBC) Multicomponent Complexation and pH independent controlled release delivery system to Improved Dissolution and oral Bioavailability of Ondansetron HCI

    Adimulapu Anilkumar, Talasila Eswara Gopala Krishna Murthy, Avula Prameela Rani

    pp. 665-675 · DOI: 10.5530/ijper.50.4.19 · 2016

    The objective of this study was to develop pH independent controlled release matrix tablets of Ondansetron HCl by using Multi component Complexation technique, Methocel K100M as release retarding materials and HP β-cyclo…

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20. Formulation, Solid State Characterization and Enhancement of Dissolution Rate of Olmesartan Medoxomil by Polyvinyl Alcohol-Polyethylene Glycol Graft Copolymer Based Nanoparticles

    Aparna Ashok chavan, Amol Somanath Shete, Bhagyesh Uttamrao Janugade, Rajendra Chandrashekar Doijad

    pp. 676-688 · DOI: 10.5530/ijper.50.4.20 · 2016

    The objectives of present investigation were to prepare and evaluate nanoparticles of Olmesartan medoxomil (OLM) by a precipitation method using polyvinyl alcohol- polyethylene glycol graft copolymer (Kollicoat IR) and t…

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