Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents
1, 1
- 1Department of Pharmaceutical Chemistry, PES Modern College of Pharmacy, Pune, Maharashtra, INDIA.
CORRESPONDENCE
Mr. Vaibhav Gawade PhD Scholar
Department of Pharmaceutical Chemistry, PES Modern College of Pharmacy, Pune-44, Maharashtra, INDIA.
Received: 29-09-2023; Accepted: 25-04-2024.
Volume 58, Issue 3 · pp. 837-853 · 2024 · DOI: 10.5530/ijper.58.3.92
ABSTRACT
Background: The biological activity of thiophene and carbohydrazide derivatives is well known; some of them are included in various anticancer drugs.Objectives: The main goal of this work was to develop effective, effective and non-toxic compounds with anti-cancer properties. To achieve this goal, we synthesized a new series of N2, N5-bis(1E)- ethylidene thiophene-2,5-dicarbohydrazide derivatives.Materials and Methods: Thiophene-2,5-dicarbohydrazide reacts with aromatic aldehydes and ethanol to form a new series of derivatives. This work examined the compounds obtained for them in vitro cytotoxic activity against the breast cancer lines MCF-7.Results: The results of antiproliferative cell inhibition studies showed that some compounds showed high activities compared to standard imatinib drugs.Conclusion: The most promising compounds D1-D10 were selected to study their inhibitory effects on the MCF-7 cell line, where compound D5 showed the highest activity. All synthesized compounds have no adverse effect on normal cell lines.
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Gawade, V., & Chopade, V. (2024). Design and Synthesis of Novel Series of Thiophene-2, 5-dicarbohydrazide Derivatives as Potential Anticancer Agents. Indian Journal of Pharmaceutical Education and Research, 58(3), 837-853. https://doi.org/10.5530/ijper.58.3.92
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