Table of Contents

Original Article(continued)

1. Peiminine Alleviates Breast Carcinoma via Reprogramming the PI3K/Akt/mTOR Pathway in vitro and in vivo

   Wenming Zhao, Jirui Sun, Binjuan Zhou, Haizhi Qiao, Jinmei Li, Shuangqiu Ma, Jinku Zhang

   pp. 210-220 · DOI: 10.5530/ijper.20255151 · 2025

   Background: The breast cancer is most frequently diagnosed cancer in the women worldwide. Our study investigated the anticancer effect of peiminine, an alkaloid obtained from Fritillaria thunbergii, against breast carcin…

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2. Anticancer, Apoptotic, Cell Migration and Invasion Inhibition and in silico Molecular Docking Studies of Naringetol in A-549 Human Lung Cancer Cells

   Jing Li, Beishou Wu, Xuejun Huang, Weizhong Tang

   pp. 221-229 · DOI: 10.5530/ijper.20250091 · 2025

   Aims: The main objective of this research work was to investigate the anticancer effects of Naringetol in A-549 human lung cancer cells along with evaluating its effects on cell apoptosis, cell migration and cell invasio…

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3. Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi

   Kalkatanur Ganesan Vanitha, N. Anandakumar Natarajan, Natesan Sudhakar, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Palanisamy Arulselvan, Rathinam Raja

   pp. 230-241 · DOI: 10.5530/ijper.20250286 · 2025

   Background: Trachyspermum ammi (T. ammi) holds a longstanding position in traditional medicinal practices, renowned for its diverse medicinal and pharmacological attributes. Medicinal plants not only offer significant th…

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4. Apocynin Induces Apoptosis in Human Lung Cancer A549 Cells via Regulating Apoptotic Protein and Inflammatory Cytokines

   Li Shang, Jindao Wang, Xiaoqing Liu

   pp. 242-251 · DOI: 10.5530/ijper.20250045 · 2025

   Objectives: Lung cancer, widely considered the leading cause of cancer-related deaths world wide, ranks fourth in terms of its occurrence among all types of malignant tumors. Phytochemicals are the potent alternative for…

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5. Evaluation of Antipyretic and Antioxidant Activities of Ten Indigenous Medicinal Plants of Tirtajaya, Karawang Regency, West Java, Indonesia

   Neni Sri Gunarti, Maulana Yusuf Alkandahri, Eko Sri Wahyuningsih, Putri Agustina, Iin Lidia Putama Mursal, Himyatul Hidayah, Vera Nurviana

   pp. 252-263 · DOI: 10.5530/ijper.20256381 · 2025

   Aim: This research aimed to explore the antipyretic and antioxidant activity of infusions of Chromolaena odorata (COI), Abelmoschus manihot (AMI), Annona muricata (AMCI), Allium ascalonicum (AAI), Carica papaya (CPI), Ta…

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6. Anti-Atherosclerotic Potency of Lichen Metabolite Usnic Acid against High Fat Diet Induced Atherosclerosis Rat Model

   Linna Guo, Xiaojuan Gao

   pp. 264-275 · DOI: 10.5530/ijper.20257128 · 2025

   Background: Cardiovascular diseases and its associated chronic disorders are was and tend to be a global threat for centuries. 80% of cardiovascular diseases were reported in the lower and middle income countries. Chroni…

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7. Natural Product Goniothalamin Induced NADPH-Diaphorase Expression in the Liver: A Possible Role of Nitric Oxide in Hepatoprotection

   Hui Man Yap, Abdalaziz Faleh Albalawi, Naif Hussain Alhussain, Abdullah Hamdan Alharbi, Morizeeq Ahamed Ibrahim, Mohamed Ali Seyed

   pp. 276-286 · DOI: 10.5530/ijper.20256291 · 2025

   Background/Aim: Goniothalamin (GTN) has received significant attention for its selective cytotoxicity toward multiple tumor cell lines, without causing any effect on normal cells. Despite a lack of toxicity, the poor pot…

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8. Effect of Evodiamine in the Prevention and Treatment of 5-FU Induced Diarrhea in Swiss Albino Rats: A Preliminary Study

   Bianjiang He, Ke Su, Mingming Wei, Guangya Zhou

   pp. 287-296 · DOI: 10.5530/ijper.20250135 · 2025

   Aim of the Study: To assess the antidiarrheal properties of Evodiamine in the prevention and treatment of Chemotherapy-Induced Diarrhea (CID) in experimental rats. Materials and Methods: The Swiss albino female rats (8-1…

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9. Neuroprotective Potential of Marrubium vulgare Linn. Extract against Scopolamine-Induced Alzheimer’s Type Dementia in Mice

   Yogesh Verma, Sunishtha Kalra, Himanshu Sachdeva, Praveen Kumar, Govind Singh

   pp. 297-307 · DOI: 10.5530/ijper.20255860 · 2025

   Background: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment, cognitive decline and behavioural changes. It primarily affects individuals over the age of 65. It pose…

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10. Structural Elucidation of Phytoconstituents (Phenols, Long Chain Fatty Acids, Flavonoid, Terpenoids, Coumarin) Found in Chromolaena odorata through Gas Chromatography: Mass Spectroscopy (GC-MS) Technique

    Manjushree Kundalik Pawar, Jayesh Ashok Dwivedi, Udichi Kataria Dwivedi

    pp. 308-315 · DOI: 10.5530/ijper.20254846 · 2025

    Background:Chromolaena odorata (CO) is a well-known ethnopharmacological herb in Ayurveda and exhibits a comprehensive range of therapeutic potential. Objectives: The objective of this research was to study the phytochem…

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11. In vitro Study on the Antioxidant and Anti-Inflammatory Capabilities of Borassus flabellifer Seedcoat

    Madhubala Natarajan, Arul Amutha Elizabeth

    pp. 316-325 · DOI: 10.5530/ijper.20255122 · 2025

    Aims: Borassus flabellifer, commonly known as Palmyra palm, Ice apple, Nungu (Tamil) is prevalent in South Asia. This study is focused on determining the anti-oxidant and anti-inflammatory activity of ethanolic extract i…

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12. Blockade of Multiple Pathways of P. falciparum by Quinoxaline from Curry Fish (S. hermanni) Using an in silico Approach

    Prawesty Diah Utami, Varidianto Yudo, Retno Budiarti

    pp. 326-337 · DOI: 10.5530/ijper.20255346 · 2025

    Introduction: The escalating mortality and morbidity rates due to malaria present an unsolved global health problem. Previous in vivo research has revealed the antimalarial effect of S. hermanni. However, the mechanism o…

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13. Chemical Profiling and in vitro Evaluation of the Antioxidant, Anti-Inflammatory, and Anti-Bacterial Effects of Algerian Solanum melongena L.

    Rabah Kellab, Fouzi Boulkenafet, Serine Amokrane, Zebida Benmakhlouf, Chawki Bensouici, Azeddine Bounamous, Abdelouahab Yahia, Simonetta Lambiase, Fahd Abdo Al-Meklafi, Mohammed Ahmed Wadaan

    pp. 338-350 · DOI: 10.5530/ijper.20250132 · 2025

    Aim: Solanum melongena L., commonly known as eggplant, is a low-calorie vegetable with high nutritional value due to its rich fiber, vitamins, minerals, and bioactive compounds, particularly polyphenols, which provide an…

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14. The Effect of Pistacia vera L. (Pistachio) Extract on Fatty Acid Biosynthesis and Total Proteins against Carbon Tetrachloride (CCl4)-induced Damage in Saccharomyces cerevisiae

    Zehra Gökçe

    pp. 351-358 · DOI: 10.5530/ijper.20257396 · 2025

    Background and Aim: Pistacia vera (PV) is an important species with economic value, rich compound content and high biological activity. Carbon Tetrachloride (CCl4 ) used in our study is an important reactive toxic compou…

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15. Conessine Attenuates Diabetic Nephropathy in Rats through Inhibition of Hyperglycemia-Induced Oxidative Stress, Inflammation and Apoptosis

    Lin Li, Qian Wang, Yungiang Wang, Chenchen Li, Yan Gao, Li Zhang

    pp. 359-369 · DOI: 10.5530/ijper.20250182 · 2025

    Background: One type of chronic kidney disease is diabetic nephropathy. One of the main causes of end-stage renal disease and chronic kidney disease is diabetic nephropathy. The objective of this study was to assess the …

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16. Hepatoprotective Properties of Acacia nilotica Bark Extract against H2O2 Induced Oxidative Damage in Normal Liver (LO2) and Cancer (HepG2) Cells

    Hong Jian Cai, Qian Yan, Zhongying Du, Yinghui Bi

    pp. 370-376 · DOI: 10.5530/ijper.20256767 · 2025

    Background: Liver cancer's severity has prompted interest in herbal remedies for hepatotoxicity and the disease. Acacia nilotica (Vachellia nilotica), valued for its traditional medicinal properties, particularly in its …

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17. Evaluation of Hepatoprotective Potential of Bougainvillea spectabilis Extracts against CCl4-Induced Hepatotoxicity

    Prabhat Kumar Das, Jai Singh Vaghela

    pp. 377-383 · DOI: 10.5530/ijper.20250293 · 2025

    Background: Injuries and fatalities caused by liver disease are among the highest in the globe. Every year, more than one million people lose their lives due to chronic hepatitis, which affects an estimated 500 million p…

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18. Use of Liquid Solid Technique for Development and Evaluation Study of Nifedipine Tablets to Enhance Dissolution Characteristics

    Amaresh Prusty, Susanta Kumar Panda, Sameer Kumar Prusty

    pp. 384-391 · DOI: 10.5530/ijper.20255571 · 2025

    Objectives: The current research finding suggests dissolution enhancement of nifedipine tablets using Liquid solid technique. Materials and Methods: The drug's solubility in various liquid carriers has been examined, out…

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19. A Study on the Mechanism of Herb-Partitioned Moxibustion at the Navel Based on the Gut-Brain Axis Theory in the Prevention and Treatment of Insomnia via the BDNF/TrkB Pathway

    Xiaona Ye, Chao Sun, Qingyin Liu, Yingying Zhao, Xiuqun Lin, Xinglin Zhao, Xingjun Han

    pp. 392-399 · DOI: 10.5530/ijper.20251193 · 2025

    Aim/Background: To examine the impact of navel moxibustion, a form of herb-partitioned moxibustion applied at the belly button, on Brain-Derived Neurotrophic Factor (BDNF), Tyrosine Kinase receptor B (TrkB) and 5-Hydroxy…

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20. Lidocaine Alleviates Myocardial Ischemia-Reperfusion Injury in Rats through JNK Signaling Pathway

    Jie Qi, Xiangkong Song, Qingdao Zhang, Qianqian Yang, Qingtan Zhang, Meiling Liu, Yuxia Gao

    pp. 400-406 · DOI: 10.5530/ijper.20250322 · 2025

    Aim/Background: This study aimed to explore the impact of lidocaine on rats subjected to MIR injury and to elucidate the underlying mechanisms involved in this process. The objective was to examine how lidocaine affects …

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