Table of Contents

Original Article(continued)

1. Effect of Carvacrol in Attenuating the TNF-α Induced Sarcopenia

   Ali Mufraih Albarrati, Rakan Ibrahim Nazer

   pp. 209-218 · DOI: 10.5530/ijper.20262945 · 2026

   Background: Sarcopenia is a condition characterized by muscle loss, which is accompanied by inflammation, oxidative stress, and mitochondrial dysfunction. The current treatment of sarcopenia is insufficient in handling t…

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2. Development and Characterization of Catechin-Loaded Self-Nanoemulsifying Drug Delivery System: Pharmacokinetics, Toxicity Assessment, and in vivo Anti-Ulcer Activity Evaluation

   Rashmi Pathak, Phool Chandra

   pp. 219-236 · DOI: 10.5530/ijper.20261584 · 2026

   Purpose: This research aimed to prepare catechin-loaded SNEDDS that would improve the oral therapeutic efficacy of catechin. Materials and Methods: Catechin-SNEDDS was prepared and characterized using emulsification time…

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3. Effect of Theobroma cocoa Extract on Olanzapine-Induced Metabolic Syndrome in Rats

   Varsha Patole, Sanjay Bhawar, Santosh Dighe, Rajashree Ghogare, Manisha Sonawane

   pp. 237-246 · DOI: 10.5530/ijper.20261703 · 2026

   Objectives: This study examined the effects of Theobroma cocoa hydro-alcoholic Extract (TCE) on the metabolic syndrome that rats developed because of olanzapine. Materials and Methods: Dry cocoa powder was macerated in 8…

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4. Anti-nociceptive and Anti-inflammatory Effects of Withanone in Various Nociception and Inflammation-Induced Murine Model

   Fengfeng Wang, Yunxia Zhu

   pp. 247-257 · DOI: 10.5530/ijper.20261166 · 2026

   Background: Pain is an unpleasant sensation that may result from severe or harmful stimuli. It serves as an indication that there may be a problem within the body and it can aid in ensuring the protection. Pain is a ubiq…

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5. Neuroprotective Effect of Inula racemosa on Chronic Stress-Aluminum Chloride Induced Memory Deficits

   Bhagya Venkanna Rao, Kanimozhi Loganathan, Sushma Raju, Ramya Vasudev

   pp. 258-269 · DOI: 10.5530/ijper.20261730 · 2026

   Introduction: Alzheimer's Disease (AD) is characterized by cognitive impairment resulting from the accumulation of amyloid beta and tau plaques, reduced Brain-Derived Neurotrophic Factor (BDNF) expression, neuronal death…

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6. Solid Lipid Nanoparticles of Resveratrol: Formulation, Characterization and In vitro Anti-Inflammatory Studies

   Vedanshu Malviya, Altaf Khan, Sachin Padole, Vaibhav Thakare, Tushar Gajbhiye

   pp. 270-282 · DOI: 10.5530/ijper.20261895 · 2026

   Aim: An oral administration formulation including resveratrol and solid lipid nanoparticles is the focus of this investigation. Materials and Methods: The resveratrol SLN was prepared utilizing oleic acid as the surfacta…

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7. In vitro Anti-oxidant, Antimicrobial, in silico Molecular Docking Analysis, and Phylogenetic Analysis of Anoectochilus elatus

   Sathishkumar Muthusamy, Selvi Sellappan, Palanisamy Arulselvan, Abdullah A Alarfaj

   pp. 283-293 · DOI: 10.5530/ijper.20262104 · 2026

   Background: Medicinal plants have long been valued for their therapeutic properties, offering a rich reservoir of bioactive compounds. Across millennia, diverse cultures worldwide have developed intricate systems of trad…

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8. Antioxidant and Anti-Inflammatory Efficacy of Dipsacoside B in Ameliorating Myocardial Infarction in an in vivo Model

   Xiao Han, Fang Chen, Jinying Zhao

   pp. 294-304 · DOI: 10.5530/ijper.20262103 · 2026

   Background: Myocardial Infarction (MI) is a severe coronary ailment associated with a great risk of mortality, often contributing to sudden cardiac death. Cardiovascular diseases account for approximately 32% of global d…

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9. Morpho-Genetic Variability in Phytochemical Composition and Essential Oils of Three Common Lavandula Species Cultivated in Van, Türkiye

   Lutfi Nohutcu, Murat Tuncturk, Ruveyde Tuncturk, Ezelhan Selem

   pp. 305-311 · DOI: 10.5530/ijper.20261158 · 2026

   Background: Lavandula sp. is a valuable plant species as ornamental plant with beautiful inflorescence and aromatic plant with high yield of essential oil. Lavender is mostly produced in Europe, the Middle East, Asia, No…

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10. Monoterpene Α-Pinene Alleviates Diabetic Retinopathy in Rodent Model via Attenuating Hyperglycemia Induced VEGF Signaling

    Xiao Dong, Zhanrong Zhang

    pp. 312-321 · DOI: 10.5530/ijper.20261413 · 2026

    Background: Diabetic Retinopathy (DR) has emerged as a significant global health issue that requires urgent and collaborative action to tackle. As the leading causes of preventable blindness, DR predominantly impacts adu…

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11. PPAR-γ and GLUT-4 Mediated Insulin Sensitizing Action of Paspalum scrobiculatum Grains; An In vivo and In silico Study towards Validating it as a Long-Term Therapy for Type 2 Diabetes

    Jyothi Reddy Gangavaram, Gourelly Latha, Mangari Pooja, Somanjeri Nithya, Allagadda Rajasekhar, Kesavan Bhaskar Reddy

    pp. 322-335 · DOI: 10.5530/ijper.20261128 · 2026

    Purpose: Insulin Resistance (IR) usually results from a decline in levels of critical signalling proteins, their functional modifications, or both. Food and drinks rich in fat, energy and/or sugars increases the risk of …

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12. Exosomal miR-34b-5p from Bone Marrow Mesenchymal Stem Cells Attenuates Spinal Cord Injury via MAPK/PI3K/ AKT Pathway Modulation

    Ming Cheng, Long Jia, Tao Yang, Xue Zhou, Ling Zeng, Hua Lu, Nianchi Wen, Benxiang He

    pp. 336-347 · DOI: 10.5530/ijper.20262022 · 2026

    Introduction: Bone Marrow Mesenchymal Stem Cells (BMMSCs) promote Spinal Cord Injury (SCI) recovery via exosomes containing bioactive molecules. This study examined the role and mechanisms of BMMSC-derived exosomes overe…

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13. Atractylenolide III Relieves Diphenoxylate-Induced Constipation via Gut Microbiota and Bile Acid Pathway Modulation

    Simin Chen, Zhibin Zhang, Jun Pang, Lina Guan, Qingfeng Wu, Qiuxiao Wang, Qian Li, Xuegui Tang

    pp. 348-360 · DOI: 10.5530/ijper.20251336 · 2026

    Aim/Background: An imbalance of intestinal flora and its fermentation products can disrupt intestinal peristalsis and lead to constipation. This study aimed to investigate how Atractylenolide Ⅲ (ATL-Ⅲ) may enhance consti…

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14. Molecular Docking, Synthesis and Determination of Anticancer Potential of Novel Pyrimidine Derivatives: In vitro and in silico Characterization

    Machhindra Holam, Sunil Galatage, Supria Gaud, Sanika Kumbhar, Aishwarya Devaru, Saniya Inamdar, Sushma Dokare

    pp. 361-373 · DOI: 10.5530/ijper.20260733 · 2026

    Background: Lung and colon carcinoma are leading causes of mortality among all cancers and cases are increasing drastically. Chemotherapy plays vital role in the treatment of carcinoma and a new series of pyrimidine hete…

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15. In vitro and in silico Analysis Alnustone Induced Anticancer Effects in Human Gastric Cancer

    Na Xu, Yixiu Zhao

    pp. 374-382 · DOI: 10.5530/ijper.20251185 · 2026

    Background: A growing number of people are at risk for gastrointestinal disorders due to dietary modifications and excessive consumption of processed food. Gastric Cancer (GC) ranks fifth in terms of frequency of diagnos…

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16. Targeting Alpha-Amylase: Discovering Novel Inhibitors through E-Pharmacophore Modeling and in vitro studies

    Norah Saeed Al-Zahrani, Basiouny El-Gamal, Mohamed Abd Ellatif, Mohamed Babiker Abd Elrouf, Alam Eldin Musa Mustafa Musa, Niemat Mohammed Tahir Ali, Marya Ahsan, Ayaz Khurram Mallick, Ayyub Ali Patel, Safaa Omer, Muniera Mohieldeen, Hagar Mohamed Mohamed, Marwa Saeed, Safa Mousa Al-Haider, Mohammed Abdullah Alshehri

    pp. 383-392 · DOI: 10.5530/ijper.20261204 · 2026

    Background: Diabetes mellitus is a metabolic disorder affecting millions worldwide, with prevalence continuing to rise globally. A major therapeutic challenge is controlling postprandial blood glucose spikes that contrib…

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17. Deciphering Key Protein Targets, Hub Gene Networks, Signaling Pathways and in silico Docking Studies of Artemisinin in Human Lung Carcinoma

    Xin Sheng, Dandan Sheng, Ruiqing Xing

    pp. 393-409 · DOI: 10.5530/ijper.20261248 · 2026

    Background: Artemisinin has been reported to exert potent anticancer effects in diverse cancers, but its mode of anticancer action is not fully understood. Objectives: This study involved network pharmacology, bioinforma…

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18. Investigatıon of the Protective Effect of Hydrogen Sulphide Donor Sodium Hydrosulphide and Sulfurized Apricot on Experimental Acute Kidney Injury Induced by Cisplatin in Rats

    Nihan Celikoz, Yakup Yilmaztekin, Ozlem Cankaya, Aslı Taslidere, Rumeyza Hilal Datli, Ayse Burcin Uyumlu, Metin Fikret Genc, Kadir Batcioglu

    pp. 410-420 · DOI: 10.5530/ijper.20261390 · 2026

    Background: In the present study, we aimed to investigate the protective effect of Hydrogen sulfide (H2S) donor Sodium Hydrosulphide (NaHS) and Sulfurized Apricot (SA) on experimental acute kidney injury induced by cispl…

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19. Bilobetin Shows Immunomodulatory and Chemopreventive Activities in Benzo(a)pyrene-Induced Lung Cancer in Mice Model

    Zhenjie Xu, Lihuan Zhu, Shentao Wang

    pp. 421-430 · DOI: 10.5530/ijper.20262240 · 2026

    Background: Lung cancer, a malignancy resulting from the uncontrolled growth of cells in pulmonary tissues, remains to be a primary cause of cancer-associated deaths worldwide, requiring a thorough understanding of its c…

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20. A Validated HPTLC Method for Simultaneous Estimation of Berberine and Trigonelline in Polyherbal Mixture A Tool for Quality Control and Standardization

    Sneha Basangouda Patil, Sunil Satyappa Jalalpure, Priya Prakash Shetti

    pp. 431-441 · DOI: 10.5530/ijper.20260726 · 2026

    Introduction: Berberis aristata and Trigonella foenumgrecum have been used in traditional medicine for various purposes due to their diverse therapeutic benefits such as anti- inflammatory, antidiabetic, antihypertensive…

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